1. Protein oxidation and degradation during aging: role in skin aging and neurodegeneration
- Author
-
Isabella Ziaja, Rebecca Widmer, and Tilman Grune
- Subjects
Aging ,Proteasome Endopeptidase Complex ,Amyloid beta-Peptides ,Chemistry ,Neurodegeneration ,Brain ,Proteins ,Neurodegenerative Diseases ,General Medicine ,Oxidative phosphorylation ,Protein aggregation ,Fibroblasts ,medicine.disease ,Protein oxidation ,Biochemistry ,Skin Aging ,Proteasome activity ,Proteasome ,Skin Physiological Phenomena ,medicine ,Degradation (geology) ,Humans ,Protein Structure, Quaternary ,Skin - Abstract
During aging, the products of oxidative processes accumulate and might disturb cellular metabolism. Among them are oxidized proteins and protein aggregates. On the other hand, in a functioning metabolic system oxidized proteins are degraded, mainly by the proteasome. During aging, however, proteasome activity declines. Therefore, the ability to degrade oxidized proteins is attenuated. The following review summarises the accumulation of oxidized proteins and the decline of the proteasomal system during skin and brain aging including some age-related neurodegenerative processes. The role of protein aggregates will be discussed as a potential reason for the accelerated dysfunction of tissue during aging.
- Published
- 2006