1. Childhood trauma and emotional processing circuits in schizophrenia: A functional connectivity study.
- Author
-
Cancel A, Comte M, Boutet C, Schneider FC, Rousseau PF, Boukezzi S, Gay A, Sigaud T, Massoubre C, Berna F, Zendjidjian XY, Azorin JM, Blin O, and Fakra E
- Subjects
- Adult, Adult Survivors of Child Abuse psychology, Amygdala diagnostic imaging, Cerebral Cortex diagnostic imaging, Female, Humans, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual physiology, Young Adult, Adult Survivors of Child Adverse Events psychology, Amygdala physiopathology, Cerebral Cortex physiopathology, Connectome methods, Emotions physiology, Schizophrenia physiopathology
- Abstract
Childhood trauma strongly impacts emotional responses in schizophrenia. We have explored an association between early trauma and the amygdala functional connectivity using generalized psychophysiological interaction during an emotional task. Twenty-one schizophrenia patients and twenty-five controls were included. In schizophrenia patients, higher levels of sexual abuse and physical neglect during childhood were associated with decreased connectivity between the amygdala and the posterior cingulate/precuneus region. Additionally, patients showed decreased coupling between the amygdala and the posterior cingulate/precuneus region compared to controls. These findings suggest that early trauma could impact later connectivity in specific stress-related circuits affecting self-consciousness and social cognition in schizophrenia., (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF