1. Tissue characterization of skin ulcer for bacterial infection by multiple statistical analysis of echo amplitude envelope
- Author
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Tadashi Yamaguchi, Takabumi Kubo, Masushi Kohta, Toshimichi Ishiguro, Kenji Yoshida, Masaaki Omura, Kazuto Kobayashi, and Naohiro Hozumi
- Subjects
010302 applied physics ,Physics ,business.industry ,Ultrasound ,Echo (computing) ,General Engineering ,Analytical chemistry ,General Physics and Astronomy ,Skin ulcer ,01 natural sciences ,Standard deviation ,Amplitude ,0103 physical sciences ,medicine ,Ultrasonic sensor ,medicine.symptom ,Center frequency ,Envelope (mathematics) ,business ,010301 acoustics ,Biomedical engineering - Abstract
To characterize skin ulcers for bacterial infection, quantitative ultrasound (QUS) parameters were estimated by the multiple statistical analysis of the echo amplitude envelope based on both Weibull and generalized gamma distributions and the ratio of mean to standard deviation of the echo amplitude envelope. Measurement objects were three rat models (noninfection, critical colonization, and infection models). Ultrasound data were acquired using a modified ultrasonic diagnosis system with a center frequency of 11 MHz. In parallel, histopathological images and two-dimensional map of speed of sound (SoS) were observed. It was possible to detect typical tissue characteristics such as infection by focusing on the relationship of QUS parameters and to indicate the characteristic differences that were consistent with the scatterer structure. Additionally, the histopathological characteristics and SoS of noninfected and infected tissues were matched to the characteristics of QUS parameters in each rat model.
- Published
- 2016
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