1. SolEmuls technology: a way to overcome the drawback of parenteral administration of insoluble drugs.
- Author
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Junghanns JU, Buttle I, Müller RH, Araújo IB, Silva AK, Egito ES, and Damasceno BP
- Subjects
- Amphotericin B administration & dosage, Candida tropicalis drug effects, Drug Combinations, Drug Stability, Emulsions, Erythrocytes drug effects, Erythrocytes metabolism, Hemoglobins metabolism, Lecithins chemistry, Microbial Sensitivity Tests, Nanotechnology methods, Particle Size, Phospholipids chemistry, Potassium metabolism, Solubility, Sorbitol chemistry, Spectrophotometry, Static Electricity, Surface Properties, Suspensions chemistry, Amphotericin B chemistry, Amphotericin B pharmacology
- Abstract
In this article, a nanosuspension of AmB was prepared and mixed with the preformed parenteral emulsion Lipofundin and subjected to high-pressure homogenization (SolEmuls technology). Characterization was performed by photon correlation spectroscopy (PCS), laser diffractometry (LD), and zeta potential measurements. Drug incorporation was studied by using light microscopy. The produced emulsions were further investigated by comparing them with the commercially available Fungizone in regard to antifungal efficiency and toxicity. Results suggest that through the SolEmuls process the AmB forms a reservoir, out of which it is released in such a manner that it is more efficient and less toxic than Fungizone.
- Published
- 2007
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