1. Re-elevation of serum amlodipine level after lipid emulsion therapy in an overdose case.
- Author
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Ando M, Nakasako S, Ariyoshi K, Yamaguchi M, Sakizono K, Minowa K, Fukushima S, Sugioka N, and Hashida T
- Subjects
- Aged, Humans, Male, Amlodipine administration & dosage, Amlodipine blood, Calcium Channel Blockers administration & dosage, Calcium Channel Blockers blood, Drug Overdose blood, Fat Emulsions, Intravenous administration & dosage, Lipids administration & dosage
- Abstract
What Is Known and Objective: Amlodipine overdose is common; however, the dose and timing of intravenous lipid emulsion (ILE) therapy as a management strategy remain debatable., Case Description: A 73-year-old man received a single bolus (1.5 mL/kg) of ILE therapy following massive ingestion of multiple drugs, including amlodipine. After approximately 20 hours of ILE therapy, the serum amlodipine level that had decreased from 90.2 to 49.9 ng/mL increased to 70.8 ng/mL., What Is New and Conclusion: A single bolus (1.5 mL/kg) of ILE therapy is probably insufficient to completely capture and partition serum amlodipine following amlodipine overdose., (© 2019 John Wiley & Sons Ltd.)
- Published
- 2019
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