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In this research, synthesis of different imidazopyridine derivatives was performed using aryl glyoxals, thiobarbituric acid, and 2-aminopyridine in the presence of acetic acid in ethanol at 80 °C. Different aryl glyoxals can be used in this method. Finally, the desired products were separated by simple filtration in excellent yields. The salient features of this protocol are a simple operation, mild reaction conditions, simple work up, easy product isolation, and preparation of potentially bioactive compounds. [ABSTRACT FROM AUTHOR]

The aim of present investigation is survey reactivity of 2-aminopyridine and Meldrum's acid in the presence of aryl glyoxals or aryl aldehydes. The ethyl 2-(3-aryl imidazo[1,2-a]pyridin-2-yl)acetates were successfully synthesized by reaction of 2-aminopyridine, Meldrum's acid, and aryl glyoxals, while the ethyl 3-aryl-3-(pyridin-2-ylamino)propanoates were synthesized in the presence of aryl aldehydes. The reactions are performed in ethanol, catalyzed by acetic acid at reflux and microwave conditions. [ABSTRACT FROM AUTHOR]