1. Removing the C-terminal protecting group enlarges the crystal size: Z-(Gly-Aib) 2 -OH·H 2 O.
- Author
-
Gessmann R, Brückner H, and Petratos K
- Subjects
- Crystallography, X-Ray, Glycine chemistry, Hydrogen Bonding, Models, Molecular, Molecular Structure, Oligopeptides chemical synthesis, Protein Conformation, Aminoisobutyric Acids chemistry, Glycine analogs & derivatives, Oligopeptides chemistry
- Abstract
The achiral tetrapeptide monohydrate N-(benzyloxycarbonyl)glycyl-α-aminoisobutyrylglycyl-α-aminoisobutyric acid monohydrate, Z-Gly-Aib-Gly-Aib-OH·H
2 O (Z is benzyloxycarbonyl, Aib is α-aminoisobutyric acid and Gly is glycine) or C20 H28 N4 O7 ·H2 O, exhibits two conformations related by the symmetry operation of an inversion centre. It adopts only one of two possible intramolecular hydrogen bonds in a type I (and I') β-turn and forms a maximum of intermolecular hydrogen bonds partly mediated by water. The space group, the molecular structure and the crystal packing differ from two already described (Gly-Aib)2 peptides which vary only in the protecting groups. This structure confirms the high structural flexibility of Gly-Aib peptides and points to a strong relationship between intermolecular hydrogen bonding and crystal quality and size.- Published
- 2020
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