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11 results on '"Neuhaus O"'

1. Induced transport of amino acids in rat liver after whole-body gamma irradiation.

Author

Flory W and Neuhaus OW

Subjects
Aminoisobutyric Acids metabolism, Animals, Biological Transport, Active, Bridged Bicyclo Compounds metabolism, Cesium Radioisotopes, Cycloleucine metabolism, Gamma Rays, Male, Methionine metabolism, Rats, Sodium, Amino Acids metabolism, Liver metabolism, Radiation Effects
Published
1976

4. Hormonal regulation of hepatic amino acid transport.

Author

Kilberg MS and Neuhaus OW

Subjects
Aminoisobutyric Acids analogs & derivatives, Aminoisobutyric Acids metabolism, Animals, Biological Transport drug effects, Cyclic AMP metabolism, Diabetes Mellitus, Experimental metabolism, Glucagon antagonists & inhibitors, Leucine analogs & derivatives, Leucine metabolism, Perfusion, Rats, Sodium pharmacology, Amino Acids metabolism, Glucagon pharmacology, Insulin pharmacology, Liver metabolism
Abstract

The transport of 2-aminoisobutyric acid (AIB) into liver tissue was increased by both insulin and glucagon. We have now shown that these hormones do not stimulate the same transport system. Glucagon, possibly via cAMP, increased the hepatic uptake of AIB by a mechanism which resembled system A. This glucagon-sensitive system could be monitored by the use of the model amino acid MeAIB. In contrast, the insulin-stimulated system exhibited little or no affinity for MeAIB and will be referred to as system B. On the basis of other reports that the hepatic transport of AIB is almost entirely Na+ dependent and the present finding that the uptake of 2-aminobicyclo [2,2]heptane-2-carboxylic acid (BCH) was not stimulated by either hormone, we conclude that system B is Na+ dependent. Furthermore, insulin added to the perfusate of livers from glucagon-pretreated donors suppressed the increase in AIB or MeAIB uptake. Depending upon the specificities of systems A and B, both of which are unknown for liver tissue, the insulin/glucagon ratio may alter the composition of the intracellular pool of amino acids.

Published
1977
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5. Hormonal control of amino acid transport in the liver of rats exposed to whole-body gamma irradiation.

Author

Kilberg MS and Neuhaus OW

Subjects
Aminoisobutyric Acids metabolism, Animals, Corticosterone blood, Cyclic AMP metabolism, Diabetes Mellitus, Experimental metabolism, Gamma Rays, Glucagon blood, Growth Hormone blood, Insulin blood, Insulin pharmacology, Liver radiation effects, Male, Rats, Amino Acids metabolism, Biological Transport radiation effects, Glucagon metabolism, Liver metabolism
Published
1978

6. In vitro uptake of model amino acids by rat liver following whole-body -irradiation.

Author

Yang KP and Neuhaus OW

Subjects
Animals, Biological Transport, Active, Carbon Isotopes, Cycloheximide pharmacology, Dinitrophenols pharmacology, Extracellular Space analysis, In Vitro Techniques, Kinetics, Male, Ouabain pharmacology, Potassium metabolism, Rats, Sodium metabolism, Uncoupling Agents pharmacology, Amino Acids metabolism, Aminoisobutyric Acids metabolism, Liver metabolism, Radiation Effects
Published
1971

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