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Nitrones derived from aromatic or aliphatic aldehydes or ketones react with hexafluoropropene (HFP) or 2H-pentafluoropropene (PFP) to give the respective fluorinated isoxazolidine derivatives in good yields with complete regioselectivity and moderate diastereoselectivity. Catalytic hydrogenolysis of the NO bond under ambient pressure and temperature leads to fluorides of β-amino acids that undergo cyclization to α-trifluoromethylated β-lactams or, under acidic conditions, form esters of α-trifluoromethylated β-amino acids. [ABSTRACT FROM AUTHOR]