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The aim of the research was to evaluate the effects of ethanol and the amino acids mixture (GABA, glutamine, β-alanine) on alloxan-induced diabetes in laboratory rats, study of changes in animal behavior with "Open field" test, investigate the white blood cells differential count (the blood differential test), which are indicators of pathophysiological processes. The "Open field" test showed that alloxan decreases the motor, orientation-exploratory activity of animals, suppresses emotions, and causes depression. Single intraperitoneal injection of ethanol, as well as the amino acid mixture to alloxan-induced diabetic rats have a hypoglycemic effect, significantly (p<0,001) reducing the blood glucose level by 26% and 33% respectively. However, these substances did little to improve the motor-exploratory behavior of animals, as well as changes in the differential count of lymphocytes. These data serve as the basis for studies with long-term daily use of the above mentioned substances. [ABSTRACT FROM AUTHOR]

The administration of montmorilonit with food and β-alanine and GABA-T inhibitor ethanolamine-O-sulfate (EOS) with water to rats prevents the hyperglycemic effect of chemical diabetogen streptozotocin intraperitoneal injection. Streptozotocin injection to intact rats statisticaly proven decreases the level of neuroactive amino acids in brain and pancreas. Referred to above food additive prevents such effect of streptozotocin and its inhibitory action on the glutamate utilization by brain and pancreas homogenates. Obtained data testify the preventive action of used food additive on the diabetes mellitus initiation by streptozotocin. [ABSTRACT FROM AUTHOR]