1. Superacid-Catalyzed Trifluoromethylthiolation of Aromatic Amines.
- Author
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Bonazaba Milandou, Longin Justin Clair, Carreyre, Hélène, Alazet, Sébastien, Greco, Gino, Martin‐Mingot, Agnès, Nkounkou Loumpangou, Célestine, Ouamba, Jean‐Maurille, Bouazza, Fodil, Billard, Thierry, and Thibaudeau, Sébastien
- Subjects
SUPERACIDS ,SULFENAMIDES ,TRIFLUOROMETHYL compounds ,AMINES ,AROMATIC amines ,NUCLEAR magnetic resonance spectroscopy - Abstract
Upon activation under superacid conditions, functionalized tailor-made N-SCF
3 sulfenamides served as reagents for the trifluoromethylthiolation of aromatic amines. This method has a broad substrate scope and can be used for the late-stage functionalization of complex molecules such as alkaloids or steroids. Mechanistic studies based on in situ low-temperature NMR spectroscopy revealed the involvement of dicationic superelectrophilic intermediates. [ABSTRACT FROM AUTHOR]- Published
- 2017
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