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1. Commercial synthesis of nitrazepam via interaction of 2-chloro-5-nitrobenzophenone with ethylenediamine.

Author

Anikeev, V., Petrunin, A., Zhukov, Y., Kilin, M., and Guss, F.

Subjects
*BIOSYNTHESIS, *PHARMACOLOGY, *METHODOLOGY, *OXIDATION, *AMINES, *DRUGS
Abstract

A commercial synthesis of nitrazepam has been developed based on the interaction of 2-chloro-5-nitrobenzophenone with ethylenediamine and the subsequent oxidation of intermediate benzodiazepine to benzodiazepinone. The proposed method has been successfully implemented in practice. [ABSTRACT FROM AUTHOR]

Published
2005
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