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1. Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo.

Author

Luo X, Wang W, Dorkin JR, Veiseh O, Chang PH, Abutbul-Ionita I, Danino D, Langer R, Anderson DG, and Dong Y

Subjects
Animals, Mice, Nanostructures administration & dosage, RNA, Small Interfering chemistry, Amines chemistry, Nanostructures chemistry, Polymers chemistry, RNA, Small Interfering administration & dosage
Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

Published
2016
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