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The Pd‐catalyzed cross‐coupling reaction of 1, 2‐di(pyrimidin‐2‐yl) disulfides with heterocyclic amines including 2‐amino pyrimidines and 1,3,4‐thiadiazol‐2‐amines to deliver symmetrical C‐N coupling products in moderate to good yields is reported. This method provides an opportunity for synthesis of bioactive molecules and pharmaceutically interesting compounds containing heterocycle motifs. The reported protocol shows good functional group compatibility, and provides a new strategy for preparation of C2‐amination pyrimidine derivatives from heterocyclic disulfides. [ABSTRACT FROM AUTHOR]

Review: [26 refs. [ABSTRACT FROM AUTHOR]

The allylation reaction proceeds with high regioselectivity and has a broad substrate scope. [ABSTRACT FROM AUTHOR]

(2-Chlorobenzoyloxy)copper(I) exhibited high activity towards the challenging amination of 2-amino pyrimidines with aryl halides. Herein, secondary and tertiary amines were selectively produced by using potassium phosphate and sodium- t -butoxide. Potassium phosphate favored the formation of secondary amines, whereas tertiary amines were favored when sodium- t -butoxide was used. [ABSTRACT FROM AUTHOR]

A protocol for chemoselective transformation of disulfides into aryl and alkyl amines is developed. [ABSTRACT FROM AUTHOR]

The reaction is not sensitive to steric or electronic effects of the substituents. [ABSTRACT FROM AUTHOR]

It is found that potassium phosphate used as base favors the formation of secondary amines (III), (VI), whereas tertiary amines (IV),(VII) are obtained when tBuONa is used. [ABSTRACT FROM AUTHOR]

The mechanism of the unexpected deacylation observed in the reactions using methylglyoxal (V) remains unclear. [ABSTRACT FROM AUTHOR]

An abstract of the article "Ligand-Free CuTC-Catalyzed N-Arylation of Amides, Anilines and 4-Aminoantipyrine: Synthesis of N-Arylacrylamides, 4-Amido-N-phenylbenzamides and 4-Amino(N-phenyl) antipyrenes" by Zheng-Jun Quan, Hai-Dong Xia and colleagues is presented.

A novel method using CuSO4/sodium ascorbate as the catalyst system allows the synthesis of various secondary amides including the title amides, which are difficult to obtain by classical methods. [ABSTRACT FROM AUTHOR]

An efficient reaction to the title compounds with high stereo- and regioselectivities is described. [ABSTRACT FROM AUTHOR]

Depending on the solvent and reaction temperature, thiones (I) react with amines (II) to yield the functionalized pyrimidine systems (III) and (IV). [ABSTRACT FROM AUTHOR]