1. Sulfanilamide copper(II) chelates with 2-[(2-hydroxyphenyl-imino)methyl]phenolom and 1-[(2-hydroxyphenylimino)-methyl]naphthalen-2-ol.
- Author
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Gulya, A. P., Tsapkov, V. I., Poirier, D., Aruksandei, K., and Pakhontsu, E.
- Subjects
SULFANILAMIDES ,COPPER ,CHEMICAL reactions ,AMIDES ,ORGANONITROGEN compounds - Abstract
2-[(2-Hydroxyphenylimino)methyl]phenol (HL) and 1-[(2-hydroxyphenylimino)methyl]naphthalen-2-ol (HL) reacted with copper(II) acetate hydrate and sulfanilamide (Sf), sulfathiazole (Sf), sulfaethidole (Sf), sulfadiazine (Sf), and sulfadimidine (Sf) in ethanol to give mixed-ligand copper chelates with the composition Cu(Sf)(L) · n HO ( n = 1, 2). All these complexes are monomeric. Salicylaldehyde imines (HL and HL) behave as doubly deprotonated tridentate O,N,O ligands, whereas sulfanilamides (Sf) are unidentate ligands. Thermolysis of the synthesized complexes includes dehydration at 70–90°C, followed by complete thermal decomposition (290–380°C). The complexes [Cu(Sf)(L)] · 2HO and [Cu(Sf)(L)] · HO at a concentration of 10 M inhibited growth and reproduction of 100% of human myeloid leukemia cells (HL-60). The inhibitory effect was 90 and 75%, respectively, at a concentration of 10 M, whereas no antitumor activity was observed at a concentration of 10 M. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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