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Your search keyword '"Keiner, Cathrine"' showing total 3 results
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3 results on '"Keiner, Cathrine"'

1. OCT Angiography to Predict Geographic Atrophy Progression using Choriocapillaris Flow Void as a Biomarker.

Author

Nattagh, Khashayar, Zhou, Hao, Rinella, Nicholas, Zhang, Qinqin, Dai, Yining, Foote, Katharina G, Keiner, Cathrine, Deiner, Michael, Duncan, Jacque L, Porco, Travis C, Wang, Ruikang K, and Schwartz, Daniel M

Subjects
AMD, OCTA, choriocapillaris, flow void, geographic atrophy, Biomedical Engineering, Opthalmology and Optometry
Abstract

PurposeTo investigate the relationship between choriocapillaris (CC) flow void (FV) percentage and geographic atrophy (GA) growth rate, and study how variations in FV percentage surrounding GA predict regional GA growth.MethodsThis prospective, longitudinal study enrolled subjects with GA secondary to nonexudative age-related macular degeneration. Optical coherence tomography angiography imaged the CC and FV percentage was evaluated using a validated algorithm. GA growth rate was measured as the difference in the square root of GA area divided by the months between baseline and follow-up imaging.ResultsTwelve eyes from 7 subjects with a mean age of 80 ± 5 years (range 74-86) were studied once at baseline and 7 to 16 months later. GA expansion rate was positively correlated with increased CC FV percentage (Spearman rank correlation coefficient r = 0.69 [P = 0.038] and 0.76 [P = 0.013]) within the 6 x 6 mm scanned macular region and the 2° margin surrounding each GA lesion, respectively. Regions with CC FV at baseline located within 480 µm from the GA margin showed 33% greater chance of becoming atrophic compared with regions within 480 µm from the GA margin that did not show CC FV at baseline.ConclusionsGA expansion rate and CC FV density throughout the macular region and surrounding the GA margin were significantly correlated. The regional magnitude of FV immediately surrounding GA was associated with GA growth into that region.Translational relevanceCC FV analysis may facilitate prediction of GA growth over time for patients with advanced nonneovascular age-related macular degeneration.

Published
2020

2. Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography.

Author

Keiner, Cathrine M, Zhou, Hao, Zhang, Qinqin, Wang, Ruikang K, Rinella, Nicholas T, Oldenburg, Catherine E, Duncan, Jacque L, and Schwartz, Daniel M

Subjects
AMD, OCT angiography, OCTA, flow void, Opthalmology and Optometry
Abstract

Purpose:To compare choriocapillaris flow voids (FV) in patients with neovascular age-related macular degeneration (AMD) with age-matched normal controls using swept-source optical coherence tomography angiography (SS-OCTA). Patients and methods:Eleven eyes of 11 subjects with neovascular AMD and 11 eyes of 11 age-similar normal subjects were imaged using SS-OCTA with a 6x6mm scanning pattern. Choriocapillaris FV, defined as a percentage of regions determined to have flow deficits divided by the total scanned region, was measured using a one standard deviation thresholding algorithm developed from a database of age-similar normal subjects. Results:Choriocapillaris FV was more extensive in patients with choroidal neovascularization (CNV) compared to age-similar normal subjects (FV: 20.56±4.95, 95% CI: 17.64-23.49 vs FV: 10.95±2.08, 95% CI: 9.73-12.18, respectively; P=0.0001). FV within a two-degree margin surrounding CNV in wet AMD subjects (FV: 35.04±9.34; 95% CI: 29.52-40.56) was increased compared to normal subjects (P

Published
2019

3. Quantifying choriocapillaris hypoperfusion in patients with choroidal neovascularization using swept-source OCT angiography

Author

Keiner,Cathrine M, Zhou,Hao, Zhang,Qinqin, Wang,Ruikang K, Rinella,Nicholas T, Oldenburg,Catherine E, Duncan,Jacque L, and Schwartz,Daniel M

Subjects
Aging, genetic structures, Prevention, OCT angiography, flow void, Clinical Ophthalmology, AMD, Neurodegenerative, eye diseases, Macular Degeneration, Clinical Research, Opthalmology and Optometry, Biomedical Imaging, 2.1 Biological and endogenous factors, sense organs, Aetiology, OCTA, Eye Disease and Disorders of Vision
Abstract

Cathrine M Keiner,1 Hao Zhou,2 Qinqin Zhang,2 Ruikang K Wang,2 Nicholas T Rinella,1 Catherine E Oldenburg,1,3 Jacque L Duncan,1 Daniel M Schwartz11Department of Ophthalmology, University of California, San Francisco, CA, USA; 2Department of Bioengineering, University of Washington, Seattle, WA, USA; 3Francis I. Proctor Foundation, University of California, San Francisco, CA, USACorrespondence: Daniel M SchwartzDepartment of Ophthalmology, University of California, 10 Koret Way, San Francisco, CA 94117, USATel +1 415 476 1152Email dan.schwartz@ucsf.eduPurpose: To compare choriocapillaris flow voids (FV) in patients with neovascular age-related macular degeneration (AMD) with age-matched normal controls using swept-source optical coherence tomography angiography (SS-OCTA).Patients and methods: Eleven eyes of 11 subjects with neovascular AMD and 11 eyes of 11 age-similar normal subjects were imaged using SS-OCTA with a 6x6mm scanning pattern. Choriocapillaris FV, defined as a percentage of regions determined to have flow deficits divided by the total scanned region, was measured using a one standard deviation thresholding algorithm developed from a database of age-similar normal subjects.Results: Choriocapillaris FV was more extensive in patients with choroidal neovascularization (CNV) compared to age-similar normal subjects (FV: 20.56±4.95, 95% CI: 17.64–23.49 vs FV: 10.95±2.08, 95% CI: 9.73–12.18, respectively; P=0.0001). FV within a two-degree margin surrounding CNV in wet AMD subjects (FV: 35.04±9.34; 95% CI: 29.52–40.56) was increased compared to normal subjects (P

Published
2019

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