1. Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease
- Author
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Ipek Gungor, Jonathan Graff-Radford, Glenn E. Smith, Massimo Filippi, Scott A. Przybelski, Lidia Sarro, Ronald C. Petersen, Tim Lesnick, Bradley F. Boeve, Kejal Kantarci, Nirubol Tosakulwong, Clifford R. Jack, Tanis J. Ferman, David S. Knopman, Samantha M. Zuk, Gungor, I, Sarro, L, Graff Radford, J, Zuk, Sm, Tosakulwong, N, Przybelski, Sa, Lesnick, T, Boeve, Bf, Ferman, Tj, Smith, Ge, Knopman, D, Filippi, Massimo, Petersen, Rc, Jack CR, Jr, and Kantarci, K.
- Subjects
Lewy Body Disease ,Male ,Pathology ,medicine.medical_specialty ,Dementia with Lewy bodies ,Clinical Neurology ,Disease ,behavioral disciplines and activities ,Article ,Age and gender ,T2* weighted gradient-recalled-echo MRI ,Alzheimer Disease ,mental disorders ,medicine ,Image Processing, Computer-Assisted ,Dementia ,Humans ,In patient ,Cerebral amyloid angiopathy ,Aged ,Cerebral Hemorrhage ,Cerebral Cortex ,business.industry ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,nervous system diseases ,Clinical neurology ,Neurology ,Female ,Neurology (clinical) ,Geriatrics and Gerontology ,Alzheimer's disease ,business ,Neuroscience ,Cerebral microbleeds - Abstract
Aim To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD). Methods Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's disease patients (n = 46) were compared for the frequency and location of CMBs. Results The frequency of one or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p Conclusion CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases.
- Published
- 2015