1. Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease.
- Author
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Burillo J, Marqués P, Jiménez B, González-Blanco C, Benito M, and Guillén C
- Subjects
- Alzheimer Disease etiology, Alzheimer Disease pathology, Animals, Autophagy, Brain pathology, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 pathology, Endoplasmic Reticulum Stress, Humans, Insulin-Secreting Cells pathology, Neurons pathology, Protein Folding, Risk Factors, Signal Transduction, Alzheimer Disease metabolism, Blood Glucose metabolism, Brain metabolism, Diabetes Mellitus, Type 2 metabolism, Insulin Resistance, Insulin-Secreting Cells metabolism, Nerve Degeneration, Neurons metabolism
- Abstract
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer's disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
- Published
- 2021
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