1. Plasma YKL-40 in the spectrum of neurodegenerative dementia
- Author
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Villar Piqué, Anna, Schmitz, Matthias, Hermann, Peter, Goebel, Stefan, Bunck, Timothy, Varges, Daniela, Ferrer, Isidro (Ferrer Abizanda), Riggert, Joachim, Llorens Torres, Franc, and Zerr, Inga
- Subjects
Lewy Body Disease ,blood [Frontotemporal Dementia] ,Male ,musculoskeletal diseases ,Prion diseases ,YKL-40 ,Short Report ,blood [Creutzfeldt-Jakob Syndrome] ,Creutzfeldt-Jakob Syndrome ,lcsh:RC346-429 ,Plasma ,blood [Alzheimer Disease] ,blood [Chitinase-3-Like Protein 1] ,Alzheimer Disease ,blood [Dementia, Vascular] ,mental disorders ,Humans ,CHI3L1 ,ddc:610 ,Chitinase-3-Like Protein 1 ,Demència ,lcsh:Neurology. Diseases of the nervous system ,Aged ,Aged, 80 and over ,blood [Biomarkers] ,blood [Lewy Body Disease] ,Dementia, Vascular ,CHI3L1 protein, human ,Neurodegenerative Diseases ,Biomarker ,Middle Aged ,Alzheimer's disease ,nervous system diseases ,Malaltia d'Alzheimer ,blood [Neurodegenerative Diseases] ,Frontotemporal Dementia ,Case-Control Studies ,Neurodegenerative dementia ,Female ,Dementia ,Biomarkers - Abstract
Background Increased plasma YKL-40 has been reported in Alzheimer’s disease (AD), but its levels in other neurodegenerative diseases are unknown. Here, we aimed to investigate plasma YKL-40 in the spectrum of neurodegenerative dementias. Methods YKL-40 was quantified in the plasma of 315 cases, including healthy controls (HC), neurological disease controls (ND), AD, vascular dementia (VaD), frontotemporal dementia (FTD), sporadic Creutzfeldt-Jakob disease (CJD) and Lewy body dementia (LBD). Diagnostic accuracy in the differential diagnostic context and influence of age and gender was assessed. Results Highest YKL-40 levels were detected in CJD, followed by LBD, VaD, AD, FTD, ND and HC. YKL-40 was associated to age but not to sex. After controlling for age, YKL-40 was significantly elevated in CJD compared to HC (p
- Published
- 2019
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