1. Outcome measures for Alzheimer's disease: A global inter‐societal Delphi consensus
- Author
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Ellison, Tim S, Cappa, Stefano F, Garrett, Dawne, Georges, Jean, Iwatsubo, Takeshi, Kramer, Joel H, Lehmann, Maryna, Lyketsos, Constantine, Maier, Andrea B, Merrilees, Jennifer, Morris, John C, Naismith, Sharon L, Nobili, Flavio, Pahor, Marco, Pond, Dimity, Robinson, Louise, Soysal, Pinar, Vandenbulcke, Mathieu, Weber, Christopher J, Visser, Pieter Jelle, Weiner, Michael, and Frisoni, Giovanni B
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Psychology ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Dementia ,Neurodegenerative ,Alzheimer's Disease ,Aging ,Brain Disorders ,Behavioral and Social Science ,Acquired Cognitive Impairment ,Clinical Research ,Health Services ,Neurosciences ,Neurological ,Humans ,Alzheimer Disease ,Quality of Life ,Consensus ,Delphi Technique ,Outcome Assessment ,Health Care ,Alzheimer's disease ,consensus ,Delphi ,dementia ,measures ,outcomes ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
IntroductionWe aim to provide guidance on outcomes and measures for use in patients with Alzheimer's clinical syndrome.MethodsA consensus group of 20 voting members nominated by 10 professional societies, and a non-voting chair, used a Delphi approach and modified GRADE criteria.ResultsConsensus was reached on priority outcomes (n = 66), measures (n = 49) and statements (n = 37) across nine domains. A number of outcomes and measurement instruments were ranked for: Cognitive abilities; Functional abilities/dependency; Behavioural and neuropsychiatric symptoms; Patient quality of life (QoL); Caregiver QoL; Healthcare and treatment-related outcomes; Medical investigations; Disease-related life events; and Global outcomes.DiscussionThis work provides indications on the domains and ideal pertinent measurement instruments that clinicians may wish to use to follow patients with cognitive impairment. More work is needed to develop instruments that are more feasible in the context of the constraints of clinical routine.
- Published
- 2023