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Your search keyword '"CANONICO, VINCENZO"' showing total 4 results
Start Over Author "CANONICO, VINCENZO" Topic alzheimer's disease
4 results on '"CANONICO, VINCENZO"'

1. Autonomic Dysfunction in Alzheimer's Disease: Tools for Assessment and Review of the Literature.

Author

Femminella, Grazia Daniela, Rengo, Giuseppe, Komici, Klara, Iacotucci, Paola, Petraglia, Laura, Pagano, Gennaro, de Lucia, Claudio, Canonico, Vincenzo, Bonaduce, Domenico, Leosco, Dario, and Ferrara, Nicola

Subjects
ALZHEIMER'S disease diagnosis, DYSAUTONOMIA, DIAGNOSIS of dementia, DIFFERENTIAL diagnosis, DIAGNOSIS of autonomic nervous system diseases, DIAGNOSIS
Abstract

Autonomic dysfunction is very common in patients with dementia, and its presence might also help in differential diagnosis among dementia subtypes. Various central nervous system structures affected in Alzheimer's disease are also implicated in autonomic nervous system regulation, and it has been hypothesized that the deficit in central cholinergic function observed in Alzheimer's disease could likely lead to autonomic dysfunction. Several feasible tests can be used in clinical practice for the assessment of parasympathetic and sympathetic functions, especially in terms of cardiovascular autonomic modulation. In this review, we describe the different tests available and the evidence from the literature which indicate a definite presence of autonomic dysfunction in dementia at various degrees. Importantly, the recognition of dysautonomia, besides possibly being an early marker of dementia, would help prevent the disabling complications which increase the risk of morbidity, institutionalization, and mortality in these individuals. [ABSTRACT FROM AUTHOR]

Published
2014
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2. Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease

Author

Leosco, Dario, Fortunato, Francesca, Rengo, Giuseppe, Iaccarino, Guido, Sanzari, Emma, Golino, Luca, Zincarelli, Carmela, Canonico, Vincenzo, Marchese, Massimo, Koch, Walter J., and Rengo, Franco

Subjects
*LYMPHOCYTES, *ALZHEIMER'S disease, *MESSENGER RNA, *LEUCOCYTES
Abstract

Abstract: Alterations in signal transduction pathway of G-protein-coupled receptors (GPCRs) have been found in the cerebrocortex and in the peripheral cultured tissues of patients with Alzheimer''s disease (AD). The G-protein-coupled receptor kinase-2 (GRK2) plays an important role in regulating the GPCRs signaling: its increased expression is associated with receptor desensitization. The aim of this study was to explore GRK2 levels in peripheral lymphocytes of AD patients and to establish a correlation between lymphocyte protein concentrations and the degree of cognitive impairment. GRK2 mRNA and protein expression were evaluated in the lymphocytes of AD patients with mild or moderate/severe cognitive impairment and in age-matched healthy subjects. Both GRK2 mRNA and protein expression were higher in AD patients lymphocytes compared to controls. Furthermore, lymphocyte GRK2 levels were significantly correlated to the degree of cognitive decline. Our preliminary data suggest that GRK2 is involved in GPCRs coupling dysfunction observed in AD patients. Further studies are needed in order to verify whether the lymphocyte GRK2 might be utilized as a novel biomarker in AD diagnosis and clinical monitoring. [Copyright &y& Elsevier]

Published
2007
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3. Autonomic dysfunction in Alzheimer's disease: tools for assessment and review of the literature

Author

Nicola Ferrara, Dario Leosco, Claudio de Lucia, Klara Komici, Paola Iacotucci, Giuseppe Rengo, Laura Petraglia, V. Canonico, Gennaro Pagano, Grazia Daniela Femminella, Domenico Bonaduce, Femminella, GRAZIA DANIELA, Rengo, Giuseppe, Komici, Klara, Iacotucci, Paola, Petraglia, Laura, Pagano, Gennaro, DE LUCIA, Claudio, Canonico, Vincenzo, Bonaduce, Domenico, Leosco, Dario, and Ferrara, Nicola

Subjects
functional recovery, Disease, Baroreflex, Bioinformatics, Alzheimer's disease, autonomic nervous system, baroreflex, orthostatic hypotension, Alzheimer Disease, Autonomic Nervous System Diseases, Humans, Clinical Psychology, Geriatrics and Gerontology, Psychiatry and Mental Health, medicine, Dementia, General Neuroscience, Dysautonomia, General Medicine, medicine.disease, Autonomic Nervous System Disease, Psychiatry and Mental health, Autonomic nervous system, Cholinergic, Differential diagnosis, medicine.symptom, Psychology, Neuroscience
Abstract

Autonomic dysfunction is very common in patients with dementia, and its presence might also help in differential diagnosis among dementia subtypes. Various central nervous system structures affected in Alzheimer's disease are also implicated in autonomic nervous system regulation, and it has been hypothesized that the deficit in central cholinergic function observed in Alzheimer's disease could likely lead to autonomic dysfunction. Several feasible tests can be used in clinical practice for the assessment of parasympathetic and sympathetic functions, especially in terms of cardiovascular autonomic modulation. In this review, we describe the different tests available and the evidence from the literature which indicate a definite presence of autonomic dysfunction in dementia at various degrees. Importantly, the recognition of dysautonomia, besides possibly being an early marker of dementia, would help prevent the disabling complications which increase the risk of morbidity, institutionalization, and mortality in these individuals.

Published
2014

4. Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease

Author

V. Canonico, Emma Sanzari, Guido Iaccarino, Franco Rengo, Massimo Marchese, Dario Leosco, Walter J. Koch, Luca Golino, Francesca Fortunato, Giuseppe Rengo, Carmela Zincarelli, Leosco, Dario, Fortunato, F, Rengo, Giuseppe, Iaccarino, Guido, Sanzari, E, Golino, L, Zincarelli, Carmela, Canonico, Vincenzo, Marchese, M, Koch, Wj, and Rengo, Franco

Subjects
Male, medicine.medical_specialty, G-Protein-Coupled Receptor Kinase 2, Lymphocyte, diagnosis/enzymology, Messenger, genetics/metabolism, Cell Separation, diagnosis/enzymology/physiopathology, Receptors, G-Protein-Coupled, G-Protein-Coupled, Alzheimer Disease, Predictive Value of Tests, Internal medicine, Aged, Biological Markers, metabolism, Cognition Disorders, Disease Progression, Female, Humans, Lymphocytes, enzymology/metabolism, RNA, Receptors, Up-Regulation, genetics, beta-Adrenergic Receptor Kinases, medicine, RNA, Messenger, Cognitive decline, Receptor, G protein-coupled receptor, G protein-coupled receptor kinase, biology, General Neuroscience, Beta adrenergic receptor kinase, medicine.disease, Endocrinology, medicine.anatomical_structure, Immunology, biology.protein, Alzheimer's disease, Signal transduction, Biomarkers
Abstract

Alterations in signal transduction pathway of G-protein-coupled receptors (GPCRs) have been found in the cerebrocortex and in the peripheral cultured tissues of patients with Alzheimer's disease (AD). The G-protein-coupled receptor kinase-2 (GRK2) plays an important role in regulating the GPCRs signaling: its increased expression is associated with receptor desensitization. The aim of this study was to explore GRK2 levels in peripheral lymphocytes of AD patients and to establish a correlation between lymphocyte protein concentrations and the degree of cognitive impairment. GRK2 mRNA and protein expression were evaluated in the lymphocytes of AD patients with mild or moderate/severe cognitive impairment and in age-matched healthy subjects. Both GRK2 mRNA and protein expression were higher in AD patients lymphocytes compared to controls. Furthermore, lymphocyte GRK2 levels were significantly correlated to the degree of cognitive decline. Our preliminary data suggest that GRK2 is involved in GPCRs coupling dysfunction observed in AD patients. Further studies are needed in order to verify whether the lymphocyte GRK2 might be utilized as a novel biomarker in AD diagnosis and clinical monitoring.

Published
2007

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