1. New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum Hance.
- Author
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Liu, Dan, Liu, Yan-Wen, Guan, Fu-Qin, and Liang, Jing-Yu
- Subjects
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LIVER tumors , *ALTERNATIVE medicine , *ANTINEOPLASTIC agents , *BIOLOGICAL models , *PHYSICAL & theoretical chemistry , *DOSE-effect relationship in pharmacology , *MEDICINAL plants , *NUCLEAR magnetic resonance spectroscopy , *PLANT extracts , *DESCRIPTIVE statistics , *IN vitro studies , *PHARMACODYNAMICS , *PREVENTION ,BREAST tumor prevention - Abstract
Abstract: Two new dimeric diarylheptanoids, named Alpinin C (1) and D (2), a new natural product of diarylheptanoid (3) along with three known diarylheptanoids (4–6) were isolated from the rhizomes of Alpinia officinarum Hance. Their structures were elucidated based on extensive spectroscopic analyses (1D and 2D NMR, HRTOFMS, IR). The isolated compounds were evaluated for their cytotoxicity against human tumor cell lines HepG2, MCF-7, T98G and B16-F10. Compound 1 showed selective cytotoxicity against cell lines of MCF-7 and T98G, while compound 6 showed significant cytotoxicity to the all tested tumor cell lines with IC50 in the range from 8.46 to 22.68μmol/L. [Copyright &y& Elsevier]
- Published
- 2014
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