1. Sphaeranthone A, a new carvotacetone from the leaves of Sphaeranthus africanus.
- Author
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Nguyen, Ngoc-Hong, Duong, Thuc-Huy, Tran, Thi-Minh-Dinh, Le, Hoang-Khai, Thach, Ut Dong, Nguyen, Khanh-Duy Kieu, and Nguyen, Huy Truong
- Subjects
MASS spectrometry ,CHEMICAL structure ,ALPHA-glucosidases - Abstract
A new carvotacetone sphaeranthone A and four known compounds 3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (2), 3-angeloyloxy-5-[3″-chloro-2″-hydroxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (3), chrysosplenol D (4), and 3-O-methylquercetin (5) were isolated from leaves of Sphaeranthus africanus growing in Vietnam. Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high-resolution mass spectroscopy as well as comparisons in literature. Compounds 1-3 were evaluated for the alpha-glucosidase inhibition. They showed moderate activity with IC
50 values of 103 ± 1.7, 146.8 ± 2.5, 49 ± 0.8 µg/mL, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2024
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