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Your search keyword '"Bustamante Ruiz, A"' showing total 2 results
Start Over Author "Bustamante Ruiz, A" Topic alpha 1-antitrypsin deficiency
2 results on '"Bustamante Ruiz, A"'

1. PI SZ phenotype in chronic obstructive pulmonary disease.

Author

Alvarez-Granda L, Cabero-Perez MJ, Bustamante-Ruiz A, Gonzalez-Lamuño D, Delgado-Rodriguez M, and García-Fuentes M

Subjects
Adult, Aged, Disease Susceptibility, Female, Humans, Infant, Newborn, Male, Middle Aged, Phenotype, Transferrin analysis, alpha 1-Antitrypsin analysis, Lung Diseases, Obstructive blood, alpha 1-Antitrypsin Deficiency
Abstract

Background: A study was undertaken to clarify whether the PI SZ phenotype of the protease inhibitor system predisposes to chronic obstructive pulmonary disease (COPD)., Methods: The prevalence of PI Z and PI SZ deficient phenotypes was investigated in a population of 702 patients with COPD followed up at the Chest Unit of a tertiary hospital and in 15400 newborn infants from the same geographical area. Individuals with deficiency were detected by screening of dried blood spots on filter paper using a comparative electro-immunodiffusion technique for alpha 1-antitrypsin and transferrin. The serum phenotype was confirmed by means of isoelectrofocusing on polyacrylamide gel., Results: Of the 702 blood samples from patients with COPD, six PI Z subjects (0.85%) and one PI SZ (0.14%) were detected. Of the 15400 samples from neonates, the number of PI Z subjects was eight (0.052%) and that of PI SZ was 24 (0.156%). The difference between the two groups was significant for PI Z but not for PI SZ., Conclusions: The data do not indicate an increased risk for development of COPD associated with the PI SZ phenotype but confirm the predisposition of PI Z individuals for the development of COPD.

Published
1997
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2. PI SZ phenotype in chronic obstructive pulmonary disease

Author

A Bustamante-Ruiz, Miguel García-Fuentes, M J Cabero-Perez, Domingo González-Lamuño, L Alvarez-Granda, and Miguel Delgado-Rodríguez

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Population, Alpha (ethology), Gastroenterology, Internal medicine, alpha 1-Antitrypsin Deficiency, Pi, medicine, Humans, Lung Diseases, Obstructive, education, Aged, chemistry.chemical_classification, COPD, education.field_of_study, Alpha 1-antitrypsin deficiency, business.industry, Respiratory disease, Infant, Newborn, Transferrin, Middle Aged, medicine.disease, Phenotype, chemistry, alpha 1-Antitrypsin, Immunology, Papers, Female, Disease Susceptibility, business
Abstract

BACKGROUND: A study was undertaken to clarify whether the PI SZ phenotype of the protease inhibitor system predisposes to chronic obstructive pulmonary disease (COPD). METHODS: The prevalence of PI Z and PI SZ deficient phenotypes was investigated in a population of 702 patients with COPD followed up at the Chest Unit of a tertiary hospital and in 15400 newborn infants from the same geographical area. Individuals with deficiency were detected by screening of dried blood spots on filter paper using a comparative electro-immunodiffusion technique for alpha 1-antitrypsin and transferrin. The serum phenotype was confirmed by means of isoelectrofocusing on polyacrylamide gel. RESULTS: Of the 702 blood samples from patients with COPD, six PI Z subjects (0.85%) and one PI SZ (0.14%) were detected. Of the 15400 samples from neonates, the number of PI Z subjects was eight (0.052%) and that of PI SZ was 24 (0.156%). The difference between the two groups was significant for PI Z but not for PI SZ. CONCLUSIONS: The data do not indicate an increased risk for development of COPD associated with the PI SZ phenotype but confirm the predisposition of PI Z individuals for the development of COPD.

Published
1997

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