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Your search keyword '"Em, Pouw"' showing total 3 results
Start Over Author "Em, Pouw" Topic allergy
3 results on '"Em, Pouw"'

1. Interpretation of skin tests to house dust mite and relationship to other allergy parameters in patients with asthma and chronic obstructive pulmonary disease

Author

Fw Dekker, Aa Kaptein, P. J. Sterk, C Hilvering, Jorrit Gerritsen, B Vanderbruggen, C.M. Roos, Plp Brand, Se Overbeek, Je Prinsen, Hjj Mengelers, E. J. Duiverman, Cla Vanherwaarden, Em Pouw, K. Knol, Pm Dejong, Sj Gans, W Vandermark, D. S. Postma, ER Bleecker, H. J. Waalkens, P.N.R. Dekhuijzen, Jh Dijkman, Hj Sluiter, Jgr Demonchy, Hughes, Dfme Schoonbrood, Jm Kouwenberg, Amj Wever, DA Meyers, Eem Vanessenzandvliet, Sj Pocock, J Kreukniet, K. F. Kerrebijn, A Degooyer, Ham Kerstjens, Hm Jansen, Gh Koeter, P. H. Quanjer, Pjfm Merkus, H Quanjer, Hf Kauffman, Jm Bogaard, and Htm Folgering

Subjects
House dust mite, COPD, Allergy, integumentary system, biology, business.industry, Immunology, Wheal Size, Eosinophil, biology.organism_classification, Immunoglobulin E, medicine.disease, respiratory tract diseases, medicine.anatomical_structure, biology.protein, medicine, Immunology and Allergy, Hay fever, business, Asthma
Abstract

Background: The relationships between allergic symptoms after exposure to house dust, allergy parameters (skin test to house dust mite [HDM], total IgE, HDM-specific IgE, and blood eosinophil counts), and several confounding variables (age, sex, smoking habits, and airway hyperresponsiveness) were evaluated in 235 patients with asthma and chronic obstructive pulmonary disease (COPD). Results: Skin tests had higher diagnostic value (sensitivity plus specificity) for symptomatic allergy than specific IgE (1.45 versus 1.36) or total IgE (1.16). The other allergy parameters gave no additional information on symptoms once the skin test was known. Expressing the skin test relative to the histamine control proved slightly better than uncorrected wheal size, but this probably has limited clinical value. The best cutoff level for a positive skin test was 0.7 when the histamine wheal size was accounted for by division, −6 mm when subtraction was used, and 7 mm for absolute wheal size. These cutoff levels proved equally applicable in various subgroups of patients with asthma and COPD. Only the skin test and female sex were independent predictors of allergic symptoms. Conclusion: We conclude that skin tests to HDM are better predictors for clinical allergy than total or specific IgE levels and eosinophil count, and that they are applicable in most patients with asthma and with COPD.

Published
1993
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2. IMPORTANCE OF TOTAL SERUM IGE FOR IMPROVEMENT IN AIRWAYS HYPERRESPONSIVENESS WITH INHALED CORTICOSTEROIDS IN ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY-DISEASE

Author

Huib Kerstjens, Jan Schouten, Paul Brand, DFME SCHOONBROOD, PJ STERK, Dirkje Postma, KF KERREBIJN, PH QUANJER, HJ SLUITER, EM POUW, CM ROOS, HM JANSEN, Degooyer, A., TW VANDERMARK, GH KOETER, PM DELONG, AMJ WEVER, JH DIJKMAN, PNR DEKHUIJZEN, HTM FOLGERING, CLA VANHERWAARDEN, SE OVERBEEK, JM BOGAARD, Hilvering, C., SJ GANS, HJJ MENGELEERS, BAHA VANDERBRUGGENBOGAARTS, Kreukniet, J., EEM VANESSENZANDVLIET, EJ DUIVERMAN, JM KOUWENBERG, JE PRINSEN, HJ WAALKENS, Gerritsen, J., Knol, K., JGR DEMONCHY, FW DEKKER, AA KAPTEIN, PJFM MERKUS, SJ POCOCK, MD HUGHES, NJ ROBINSON, ER BLEECKER, DA MEYERS, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
LUNG-FUNCTION, ALLERGY, SKIN-TEST REACTIVITY, INFLAMMATION, BUDESONIDE, HYPERREACTIVITY, REVERSIBILITY, AIR-FLOW LIMITATION, respiratory system, BRONCHODILATOR RESPONSE, respiratory tract diseases, RESPONSIVENESS
Abstract

Airways hyperresponsiveness is a hallmark of asthma, and many patients with COPD also demonstrate hyperresponsiveness. Inhaled corticosteroids improve hyperresponsiveness, but the extent of improvement may vary considerably between patients. This study was designed to determine which patient characteristics predict these differences in response. Patients with mild to moderately severe obstructive airways disease (asthma and COPD) were selected if PC20 less than or equal to 8 mg/ml and FEV(1)

Published
1995

3. INTERPRETATION OF SKIN-TESTS TO HOUSE DUST MITE AND RELATIONSHIP TO OTHER ALLERGY PARAMETERS IN PATIENTS WITH ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY-DISEASE

Author

Paul Brand, Huib Kerstjens, HM JANSEN, HF KAUFFMAN, JGR DEMONCHY, KF KERREBIJN, Quanjer, H., HJ SLUITER, EM POUW, DFME SCHOONBROOD, CM ROOS, Degooyer, A., Dirkje Postma, Vandermark, W., GH KOETER, PM DEJONG, PJ STERK, AMJ WEVER, JH DIJKMAN, PNR DEKHUIJZEN, HTM FOLGERING, CLA VANHERWAARDEN, SE OVERBEEK, JM BOGAARD, Hilvering, C., SJ GANS, HJJ MENGELERS, Vanderbruggen, B., Kreukniet, J., EEM VANESSENZANDVLIET, EJ DUIVERMAN, JM KOUWENBERG, JE PRINSEN, HJ WAALKENS, Gerritsen, J., Knol, K., AA KAPTEIN, FW DEKKER, PJFM MERKUS, PH QUANJER, SJ POCOCK, MD HUGHES, ER BLEECKER, DA MEYERS, Faculteit Medische Wetenschappen/UMCG, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
HAY-FEVER, EOSINOPHILIA, integumentary system, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, COMMUNITY POPULATION-SAMPLE, DIAGNOSIS, INTRADERMAL TESTS, respiratory tract diseases, ALLERGY, AGE, IGE LEVELS, HISTAMINE, ASTHMA, RESPIRATORY HYPERSENSITIVITY, TEST REACTIVITY, PRICK TEST, SERUM IMMUNOGLOBULIN-E
Abstract

Background: The relationships between allergic symptoms after exposure to house dust, allergy parameters (skin test to house dust mite [HDM], total IgE, HDM-specific IgE, and blood eosinophil counts), and several confounding variables (age, sex, smoking habits, and airway hyperresponsiveness) were evaluated in 235 patients with asthma and chronic obstructive pulmonary disease (COPD). Results: Skin tests had higher diagnostic value (sensitivity plus specificity) for symptomatic allergy than specific IgE (1.45 versus 1.36) or total IgE (1.16). The other allergy parameters gave no additional information on symptoms once the skin test was known. Expressing the skin test relative to the histamine control proved slightly better than uncorrected wheal size, but this probably has limited clinical value. The best cutoff level for a positive skin test was 0.7 when the histamine wheal size was accounted for by division, -6 mm when subtraction was used, and 7 mm for absolute wheal size. These cutoff levels proved equally applicable in various subgroups of patients with asthma and COPD. Only the skin test and female sex were independent predictors of allergic symptoms. Conclusion: We conclude that skin tests to HDM are better predictors for clinical allergy than total or specific IgE levels and eosinophil count, and that they are applicable in most patients with asthma and with COPD.

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