1. Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis.
- Author
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Thornton MA, Akasheh N, Walsh MT, Moloney M, Sheahan PO, Smyth CM, Walsh RM, Morgan RM, Curran DR, Walsh MT, Gleich GJ, and Costello RW
- Subjects
- Chemokine CCL26, Chemokines, CC immunology, Chemokines, CC metabolism, Eosinophils metabolism, Humans, Immunohistochemistry, Nasal Mucosa innervation, Nasal Mucosa metabolism, Nasal Provocation Tests, Nervous System metabolism, Rhinitis, Allergic, Rhinitis, Allergic, Perennial metabolism, Rhinitis, Allergic, Seasonal metabolism, Vascular Cell Adhesion Molecule-1 immunology, Vascular Cell Adhesion Molecule-1 metabolism, Allergens immunology, Eosinophils immunology, Nasal Mucosa immunology, Nervous System immunology, Rhinitis, Allergic, Perennial immunology, Rhinitis, Allergic, Seasonal immunology
- Abstract
In allergen challenged animal models, eosinophils localize to airway nerves leading to vagally-mediated hyperreactivity. We hypothesized that in allergic rhinitis eosinophils recruited to nasal nerves resulted in neural hyperreactivity. Patients with persistent allergic rhinitis (n=12), seasonal allergic rhinitis (n=7) and controls (n=10) were studied. Inferior nasal turbinate biopsies were obtained before, 8 and 48h after allergen challenge. Eight hours after allergen challenge eosinophils localized to nerves in both rhinitis groups; this was sustained through 48h. Bradykinin challenge, with secretion collection on the contralateral side, was performed to demonstrate nasal nerve reflexes. Twenty fourhours after allergen challenge, bradykinin induced a significant increase in secretions, indicating nasal hyperreactivity. Histological studies showed that nasal nerves expressed both vascular cell adhesion molecule-1 (VCAM-1) and chemokine (C-C motif) ligand 26 (CCL-26). Hence, after allergen challenge eosinophils are recruited and retained at nerves and so may be a mechanism for neural hyperreactivity., (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Published
- 2013
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