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1. A serologic weakly reactive RhD is caused by a novel RHD (c.722C>A, p.Thr241Asn) allele.

Author

Xie, Haihua, Yang, Xiaojun, Zhu, Shengting, Lin, Haibin, and Chen, Fawen

Subjects
ALLELES, BLOOD groups, RESEARCH, IMMUNOGLOBULINS, COOMBS' test, RESEARCH methodology, MONOCLONAL antibodies, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, GENOMICS, RH factor, GENES, GENOTYPES, PHENOTYPES
Abstract

Keywords: blood group genomics EN blood group genomics E31 E33 3 04/10/21 20210401 NES 210401 Weak D phenotypes occur predominantly due to amino acid changes in the transmembrane or intracellular regions of the RhD protein.1 Here we have identified a novel variant RHD allele in a 26-year-old G2P1 pregnant Chinese woman with a weak D phenotype. The RHD zygosity testing result indicated that the patient was hemizygous (RhD + / RhD-). [Extracted from the article]

Published
2021
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