1. HLA frequencies and associations in cystic fibrosis
- Author
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Adriaanse, M.P., Vreugdenhil, A.C., Groeneweg, M., Bruggenwirth, H.T., Castelijns, S.J., van der Ent, C.K., Voorter, C.E., Tilanus, M G., Kindergeneeskunde, RS: NUTRIM - R2 - Gut-liver homeostasis, RS: GROW - Oncology, and RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
- Subjects
musculoskeletal diseases ,HLA-DRB1 chains ,cystic fibrosis transmembrane conductance regulator ,ADULTS ,HLA-DQ alpha-chains ,ALLELES ,GUIDELINES ,DIAGNOSIS ,DISEASE ,cystic fibrosis ,HLA antigens ,skin and connective tissue diseases ,HLA-DQ beta-chains ,POPULATION - Abstract
Cystic fibrosis (CF) is classically attributed to the dysfunction of the single CF transmembrane conductance regulator gene. The incidence of human leukocyte antigen (HLA) polymorphisms in different CF-associated diseases raises the question of an unequal distribution of HLA genotypes in CF. This study aimed to evaluate HLA gene frequencies and possible associations in CF patients compared with a control population. Frequencies of HLA-DRB1, HLA-DQA1 and HLA-DQB1, performed by intermediate resolution typing using Luminex sequence-specific oligonucleotide, and epitope counts were similar in 340 CF patients when compared with 400 control subjects. In conclusion, HLA-DRB1, -DQA1 and -DQB1 do not seem to influence susceptibility to CF. Whether HLA plays a role in the severity of CF disease needs to be investigated.
- Published
- 2014