1. Bifunctional ligands for Pd-catalyzed selective alkoxycarbonylation of alkynes.
- Author
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Qi, Huimin, Huang, Zijun, Wang, Menglan, Yang, Peiju, Du, Chen-Xia, Chen, Shu-Wei, and Li, Yuehui
- Subjects
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PALLADIUM catalysts , *BIFUNCTIONAL catalysis , *LIGANDS (Chemistry) , *CARBONYLATION , *ALKYNES , *REGIOSELECTIVITY (Chemistry) - Abstract
Catalytic carbonylations of alkynes represent straightforward and atom-economic synthesis of α,β-unsaturated carbonyl compounds. One of the issues associated with the currently known catalytic systems is insufficient efficiency. In this context, Pd/ligand-catalyzed regioselective and efficient alkoxycarbonylation of terminal alkynes is desirable for the synthesis of α,β-unsaturated esters. Herein, we present the use of a newly designed bifunctional ligand for efficient Pd-catalyzed alkoxycarbonylation of alkynes. Both aliphatic and aromatic alkynes were smoothly transformed to the branched desired products with high selectivity (28 examples, 45–96% yields, 95.0–99.9% selectivity). [ABSTRACT FROM AUTHOR]
- Published
- 2018
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