1. A novel route to 1,4-dihydroquinoxaline for biological and electrochemical properties
- Author
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Zouitini, A., Kandri Rodi, Y., Elmsellem, H., Ouazzani Chahdi, F., Misbahi, K., Janati, A. E., Ouzidan, Y., Akhazzane, M., and Essassi, E. M.
- Subjects
quinoxaline-2,3-dione ,Alkylation ,o-phenylenediamine ,cyclo-condensation - Abstract
In this paper we describe the synthesis of new quinoxalines which can present a potential pharmacological properties The 6-methyl-1,4-dihydroquinoxaline-2,3-dione 3 was synthesized by the condensation of 4-methyl-o-phenylenediamine 1 with oxalic acid 2 under reflux in hydrochloric acid solution.Compound3 was exposed to alkylation reactions under the conditions of phase transfer catalysis using monohalogenated agents leading to alkylated products 3a-3f. Structures of the obtained products were confirmed by spectroscopic measurements., Moroccan Journal of Chemistry, Vol 5, No 3 (2017)
- Published
- 2017
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