1. A benzylisoquinoline alkaloid from Doryphora sassafras.
- Author
-
Carroll AR, Davis RA, Forster PI, Guymer GP, and Quinn RJ
- Subjects
- Alkaloids chemistry, Alkaloids pharmacology, Analgesics, Opioid chemistry, Analgesics, Opioid pharmacology, Animals, Australia, Brain drug effects, Cell Membrane drug effects, Cerebellum drug effects, Guinea Pigs, Inhibitory Concentration 50, Isoquinolines chemistry, Isoquinolines pharmacology, Mass Spectrometry, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Leaves chemistry, Receptors, Opioid, kappa physiology, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Alkaloids isolation & purification, Analgesics, Opioid isolation & purification, Isoquinolines isolation & purification, Monimiaceae chemistry, Plants, Medicinal chemistry, Quinolinium Compounds
- Abstract
Chemical investigation of the Australian rainforest plant Doryphora sassafras has resulted in the isolation of a new natural product, 2-methyl-1-(p-methoxybenzyl)-6,7-methylenedioxyisoquinolinium chloride (1). The iodide salt of compound 1 has previously been synthesized but only partially characterized. This paper reports the full spectroscopic characterization of 1 by MS, IR, UV, and NMR data.
- Published
- 2001
- Full Text
- View/download PDF