1. Aporphine alkaloids and a naphthoquinone derivative from the leaves of Phaeanthus lucidus Oliv. and their α-glucosidase inhibitory activity.
- Author
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Teerapongpisan P, Suthiphasilp V, Kumboonma P, Maneerat T, Duangyod T, Charoensup R, Promnart P, and Laphookhieo S
- Subjects
- alpha-Glucosidases, Molecular Docking Simulation, Molecular Structure, Glycoside Hydrolase Inhibitors pharmacology, Alkaloids pharmacology, Alkaloids chemistry, Aporphines pharmacology, Aporphines chemistry
- Abstract
Three previously undescribed aporphine alkaloids, phaeanthuslucidines E-G, one previously undescribed naphthoquinone derivative, phaeanthusnaphthoquinone, and three known compounds were isolated from an EtOAc extract of the leaves of Phaeanthus lucidus Oliv. The structures of all previously undescribed compounds were established through extensive spectroscopic investigations and high-resolution mass spectroscopy. The 6aR configuration of phaeanthuslucidines E-G was assigned by comparing their ECD spectra and specific rotation values with the reported known compounds. Some isolated compounds were evaluated for their α-glucosidase inhibitory activity. Among these compounds, phaeanthuslucidine E showed the highest α-glucosidase inhibitory activity with an IC
50 value of 17.9 ± 0.4 μM. The molecular docking of phaeanthuslucidine E was further studied., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Surat Laphookhieo reports financial support was provided by National Research Council of Thailand. Surat Laphookhieo reports a relationship with National Research Council of Thailand that includes: funding grants and travel reimbursement. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
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