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Your search keyword '"Notoamide"' showing total 2 results
Start Over Descriptor "Notoamide" Topic alkaloid
2 results on '"Notoamide"'

1. Bioconversion of 6-epi-Notoamide T produces metabolites of unprecedented structures in a marine-derived Aspergillus sp.

Author

Kato, Hikaru, Nakahara, Takashi, Yamaguchi, Michitaka, Kagiyama, Ippei, Finefield, Jennifer M., Sunderhaus, James D., Sherman, David H., Williams, Robert M., and Tsukamoto, Sachiko

Subjects
*ASPERGILLUS, *CHEMICAL structure, *METABOLITES, *CHEMICAL precursors, *ALKALOIDS
Abstract

We previously described the bioconversion of Notoamide T into (+)-Stephacidin A and (−)-Notoamide B, which suggested that Versicolamide B ( 8 ) is biosynthesized from 6- epi -Notoamide T ( 10 ) via 6- epi -Stephacidin A. Here we report that [ 13 C] 2 - 10 was incorporated into isotopically enriched 8 and seven new metabolites, which were not produced under normal culture conditions. The results suggest that the addition of excess precursor activated the expression of dormant tailoring genes giving rise to these structurally unprecedented metabolites. [ABSTRACT FROM AUTHOR]

Published
2015
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2. Bioconversion of 6-epi-Notoamide T produces metabolites of unprecedented structures in a marine-derived Aspergillus sp

Author

Jennifer M. Finefield, James D. Sunderhaus, David H. Sherman, Hikaru Kato, Robert M. Williams, Takashi Nakahara, Sachiko Tsukamoto, Ippei Kagiyama, and Michitaka Yamaguchi

Subjects
Bioconversion, Aspergillus, Aspergillus sp, biology, Versicolamide B, Stereochemistry, Chemistry, Alkaloid, Organic Chemistry, biology.organism_classification, Biochemistry, Notoamide, 474.73, chemistry.chemical_compound, 499.3, Drug Discovery, Gene, Notoamide T
Abstract

We previously described the bioconversion of Notoamide T into (+)-Stephacidin A and (−)-Notoamide B, which suggested that Versicolamide B (8) is biosynthesized from 6-epi-Notoamide T (10) via 6-epi-Stephacidin A. Here we report that [13C]2-10 was incorporated into isotopically enriched 8 and seven new metabolites, which were not produced under normal culture conditions. The results suggest that the addition of excess precursor activated the expression of dormant tailoring genes giving rise to these structurally unprecedented metabolites.

Published
2015

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