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1. Characterization of a Suspension Culture of Tabernaemontana elegans on Growth, Nutrient Uptake, and Accumulation of Indole Alkaloids*

Author

C. L. Louwe, Robert Verpoorte, E. R. Verhey, P. A. A. Harkes, and R. van der Heijden

Subjects
Pharmacology, Indole test, Tryptamine, endocrine system, Apparicine, biology, Stereochemistry, organic chemicals, Alkaloid, Organic Chemistry, Pharmaceutical Science, Tabernaemontana elegans, Carbohydrate, Phosphate, biology.organism_classification, complex mixtures, Analytical Chemistry, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Biochemistry, Cell culture, Drug Discovery, Molecular Medicine, heterocyclic compounds
Abstract

A suspension culture of TABERNAEMONTANA ELEGANS was characterized on growth, nutrient uptake (carbohydrate, nitrogen, and phosphate), and on accumulation of indole alkaloids. Besides tryptamine seven indole alkaloids were isolated and identified: vobasine, vobasinol, perivine, isositsirikine, apparicine, tubotaiwine, and O-acetylvallesamine. In spite of the presence of vobasinol as major product, only trace amounts of dimeric indole alkaloids could be detected. Alkaloid formation started at the early stationary phase.

Published
1989

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