1. Activity of Vinorelbine on B-Chronic Lymphocytic Leukemia Cells In Vitro
- Author
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A. Degli Innocenti o Nocentini, Valeria Santini, I. Banchelli, Ida Landini, B. Bartolozzi, and P. A. Bernabei
- Subjects
Vinca ,biology ,business.industry ,Alkaloid ,Chronic lymphocytic leukemia ,Pharmacology ,medicine.disease ,biology.organism_classification ,Vinorelbine ,In vitro ,Vinblastine ,Leukemia ,hemic and lymphatic diseases ,medicine ,Cytotoxic T cell ,business ,medicine.drug - Abstract
Vinorelbine (VNR) is a new semi-synthetic Vinca rosea alkaloid that has been employed both in combination and as a single agent, showing a significant antitumour activity. Since little is known about VNR in human leukemia, we studied the in vitro cytotoxic effect of VNR on peripheral blood lymphocytes from 18 patients affected by B-chronic lymphocytic leukemia (CLL), employing the INT assay. VNR inhibited fresh B-CLL cells from 15/18 patients in primary cultures, the ID50 doses ranging from 4 ng/ml to 83 μg/ml. These data strongly suggest that VNR could be effective in the treatment of B-CLL.
- Published
- 1999
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