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Classification of imbalanced data is an important challenge in current research. Sampling is an important way to solve the problem of imbalanced data classification, but some traditional sampling algorithms are susceptible to outliers. Therefore, an iF-ADASYN sampling algorithm is proposed in this paper. First, based on the ADASYN algorithm, we introduce the isolation Forest algorithm to overcome its vulnerability to outliers. Then, a calculation method of anomaly index which can delete outliers accurately of minority data is presented. The experimental results of four UCI public imbalanced datasets show that the algorithm can effectively improve the accuracy of the minority class, and increase the stability. In the real thrombus dataset, the AUC value of the iF-ADASYN algorithm is more significant than that of SMOTE and ADASYN algorithms, and the recognition rate of patients with thrombosis increased by 20%. The iF-ADASYN algorithm obtains better resistance to outliers than the original ADASYN algorithm. Meanwhile, it improves the accuracy of minority class decision boundary region division. [ABSTRACT FROM AUTHOR]

Bone age assessment (BAA) is an essential topic in the clinical practice of evaluating the biological maturity of children. Because the manual method is time-consuming and prone to observer variability, it is attractive to develop computer-aided and automated methods for BAA. In this paper, we present a fully automatic BAA method. To eliminate noise in a raw X-ray image, we start with using U-Net to precisely segment hand mask image from a raw X-ray image. Even though U-Net can perform the segmentation with high precision, it needs a bigger annotated dataset. To alleviate the annotation burden, we propose to use deep active learning (AL) to select unlabeled data samples with sufficient information intentionally. These samples are given to Oracle for annotation. After that, they are then used for subsequential training. In the beginning, only 300 data are manually annotated and then the improved U-Net within the AL framework can robustly segment all the 12611 images in RSNA dataset. The AL segmentation model achieved a Dice score at 0.95 in the annotated testing set. To optimize the learning process, we employ six off-the-shell deep Convolutional Neural Networks (CNNs) with pretrained weights on ImageNet. We use them to extract features of preprocessed hand images with a transfer learning technique. In the end, a variety of ensemble regression algorithms are applied to perform BAA. Besides, we choose a specific CNN to extract features and explain why we select that CNN. Experimental results show that the proposed approach achieved discrepancy between manual and predicted bone age of about 6.96 and 7.35 months for male and female cohorts, respectively, on the RSNA dataset. These accuracies are comparable to state-of-the-art performance. [ABSTRACT FROM AUTHOR]