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Although optical pure amino alcohols are in high demand due to their widespread applicability, they still remain challenging to synthesize, since commonly elaborated protection strategies are required. Here, a multi‐enzymatic methodology is presented that circumvents this obstacle furnishing enantioenriched 1,3‐amino alcohols out of commodity chemicals. A Type I aldolase forged the carbon backbone with an enantioenriched aldol motif, which was subsequently subjected to enzymatic transamination. A panel of 194 TAs was tested on diverse nine aldol products prepared through different nucleophiles and electrophiles. Due to the availability of (R)‐ and (S)‐selective TAs, both diastereomers of the 1,3‐amino alcohol motif were accessible. A two‐step process enabled the synthesis of the desired amino alcohols with up to three chiral centers with de up to >97 in the final products. [ABSTRACT FROM AUTHOR]