Search

The reactivity of the previously reported peroxo adduct [Fe III 2 (μ-O 2 )(MeBzim-Py) 4 (CH 3 CN) 2 ] 4+ (1) (MeBzim-Py=2-(2'-pyridyl)-N-methylbenzimidazole) towards aldehyde substrates including phenylacetaldehyde (PAA), hydrocinnamaldehyde (HCA), propionaldehyde (PA), 2-phenylpropionaldehyde (PPA), cyclohexanecarboxaldehyde (CCA), and para-substituted benzaldehydes (benzoyl chlorides) has been investigated. Complex 1 proved to be a nucleophilic oxidant in aldehyde deformylation reaction. These models, including detailed kinetic and mechanistic studies, may serve as the first biomimics of aldehyde deformylating oxygenase (ADO) enzymes., (© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

The reactivity of the previously reported peroxo-adduct [Fe III2 (μ-O)(μ-1,2-O2)(IndH)2(solv)2]2+ (1) (IndH = 1,3-bis(2-pyridyl-imino)isoindoline) has been investigated in nucleophilic (e.g., deformylation of alkyl and aryl alkyl aldehydes) and electrophilic (e.g. oxidation of phenols) stoichiometric reactions as biomimics of ribonucleotide reductase (RNR-R2) and aldehyde deformylating oxygenase (ADO) enzymes. Based on detailed kinetic and mechanistic studies, we have found further evidence for the ambiphilic behaviour of the peroxo intermediates proposed for diferric oxidoreductase enzymes. [ABSTRACT FROM AUTHOR]

The reactivity of the previously reported peroxo adduct [FeIII2(μ‐O2)(MeBzim‐Py)4(CH3CN)2]4+ (1) (MeBzim‐Py=2‐(2′‐pyridyl)‐N‐methylbenzimidazole) towards aldehyde substrates including phenylacetaldehyde (PAA), hydrocinnamaldehyde (HCA), propionaldehyde (PA), 2‐phenylpropionaldehyde (PPA), cyclohexanecarboxaldehyde (CCA), and para‐substituted benzaldehydes (benzoyl chlorides) has been investigated. Complex 1 proved to be a nucleophilic oxidant in aldehyde deformylation reaction. These models, including detailed kinetic and mechanistic studies, may serve as the first biomimics of aldehyde deformylating oxygenase (ADO) enzymes. [ABSTRACT FROM AUTHOR]