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2. Plausible mechanism of inactivation of plasma alpha 1-proteinase inhibitor by acrolein.

Author

Gan JC and Ansari GA

Subjects
Amino Acids analysis, Blood Proteins analysis, Chemical Phenomena, Chemistry, Histidine analysis, Humans, Lysine analysis, Pancreatic Elastase antagonists & inhibitors, alpha 1-Antitrypsin, Acrolein pharmacology, Aldehydes pharmacology, Blood Proteins antagonists & inhibitors
Abstract

Evidence is presented to show that inactivation of alpha 1-proteinase inhibitor caused by acrolein depends upon the modification of lysine and histidine residues. Approximately 90% activity was lost when twenty three lysine and eight histidine residues were modified.

Published
1987

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