Author: "Broadhurst RW" / Topic: alcohol oxidoreductases - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Broadhurst RW" Topic alcohol oxidoreductases

Author: Moretto L, Vance S, Heames B, and Broadhurst RW
Subjects: Binding Sites, Protein Conformation, Protein Structure, Tertiary, Substrate Specificity, Acyl Carrier Protein chemistry, Alcohol Oxidoreductases metabolism, Bacterial Proteins metabolism
Abstract: Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the pendant 5'-phosphopantetheine prosthetic group plays a key role in delivering acyl substrates to the active site in the correct orientation.
Published: 2017
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Author: Moretto, L, Vance, S, Heames, B, Broadhurst, RW, Broadhurst, Bill [0000-0002-0264-4593], and Apollo - University of Cambridge Repository
Subjects: Alcohol Oxidoreductases, Binding Sites, Bacterial Proteins, Protein Conformation, Acyl Carrier Protein, health care economics and organizations, Protein Structure, Tertiary, Substrate Specificity
Abstract: Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the pendant 5′-phosphopantetheine prosthetic group plays a key role in delivering acyl substrates to the active site in the correct orientation., The authors would like to thank the Wellcome Trust (grant number 094252/Z/10/Z) for funding this research. LM was supported by an EPSRC PhD studentship.
Published: 2018
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