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There is no doubt that air pollutants have adverse impacts on human health. The main objective of this study was to evaluate hospital admission respiratory disease (HARD) attributed to sulfur dioxide levels in Ahvaz during three successive years. Data was taken from Iranian Environmental Protection Agency (EPA). The AirQ2,2,3 model is used to quantify the impact of SO 2 on inhabitants of Ahvaz and in terms of hospital admission respiratory diseases. This is a kind of statistical model which is based on some epidemiological indices such as relative risk, baseline incidence, and attributable proportion. Sampling was already performed for 24 h in four stations during 2011-2013. Four stations are good representative for residential, high traffic, industry, and background sites which cover the whole area of the Ahvaz city. Regarding to gravimetric scale, raw data of sulfur dioxide was processed using Excel software. Encoding, filtering, and processing were conducted to prepare input file for the Air Q 2,2,3 model. After running model, outputs presented in term of hospital admissions respiratory cases. Based on our result, the highest mean and maximum of seasonal and annual levels for sulfur dioxide were observed in 2013. We concluded that obnoxious quality of fuel and some deficiencies in maintenance and operation of industries lead to worse quality of ambient air especially in 2013. Cumulative cases of HARD attributed to sulfur dioxide level at central of relative risk (RR) were estimated 24, 25, and 30 persons for 2011, 2012, and 2013, respectively. The finding of this study showed that total mean of sulfur dioxide was higher than standard concentration. We also noticed that wintertime concentrations of sulfur dioxide during three successive years were higher than of those levels in summer.