1. Brief Report: CD14+ Enriched Peripheral Cells Secrete Cytokines Unique to HIV-Associated Neurocognitive Disorders.
- Author
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Agsalda-Garcia MA, Sithinamsuwan P, Valcour VG, Chalermchai T, Tipsuk S, Kuroda J, Nakamura C, Ananworanich J, Zhang G, Schuetz A, Slike BM, and Shiramizu B
- Subjects
- AIDS Dementia Complex physiopathology, Cytokines, Gene Expression Profiling, HIV Infections physiopathology, Humans, Monocytes, Viral Load, AIDS Dementia Complex metabolism, HIV Infections metabolism, Leukocytes, Mononuclear metabolism, Lipopolysaccharide Receptors metabolism
- Abstract
Monocytes play a vital role in HIV-associated neurocognitive disorder (HAND), postulated to transport HIV into the brain and secrete pro-inflammatory cytokines. We analyzed cytokines released by cultured peripheral blood mononuclear cells enriched with the CD14 marker isolated from HIV-infected individuals with HAND and normal cognition (NC) in combination antiretroviral therapy naive and after 1 year on treatment. Interleukin-8 and monocyte chemoattractant protein-1 levels were higher in HAND compared with NC at baseline (P = 0.002 and P < 0.0001). These cytokines remained higher in HAND patients 1 year after combination antiretroviral therapy and were significant when NC patients who were initially HAND were excluded (P = 0.012 and P = 0.002). Both correlated with baseline CD14 peripheral blood mononuclear cell HIV DNA levels supporting the role of HIV DNA reservoir size and monocyte cytokines in HAND persistence.
- Published
- 2017
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