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The article discusses the controversy regarding the origins of the AIDS viruses, HIV-1 and HIV-2. According to some theories and explanation, HIV-1 and HIV-2 are ancient human viruses originated in central and west Africa which spread throughout Europe. In addition, it is plausible that AIDS epidemic started through a hostile power in 1970 in the U.S.

Background: Urogenital schistosomiasis and HIV/AIDS infections are widespread in sub-Saharan Africa (SSA) leading to substantial morbidity and mortality. The co-occurrence of both diseases has led to the possible hypothesis that urogenital schistosomiasis leads to increased risk of acquiring HIV infection. However, the available evidence concerning this association is inconsistent. The aim of this study was to systematically review and quantitatively synthesize studies that investigated the association between urogenital schistosomiasis and HIV/AIDS infection. Methods: A systematic review basing on PRISMA guidelines was conducted. It is registered with PROSPERO, number CRD42018116648. We searched four databases, MEDLINE, EMBASE, Global Health and Global Index Medicus for studies investigating the association between urogenital schistosomiasis and HIV infection. Only studies published in English were considered. Results of the association were summarised by gender. A meta-analysis was performed for studies on females using random-effects model and a pooled OR with 95% confidence interval was reported. Results: Of the 993 studies screened, only eight observational studies met the inclusion criteria. Across all studies, the reported unadjusted OR ranged from 0.78 to 3.76. The pooled estimate of unadjusted OR among females was 1.31 (95% CI: 0.87–1.99). Only four of the eight studies reported an adjusted OR. A separate meta-analysis done in the three studies among females that reported an adjusted OR showed that the pooled estimate was 1.85 (95% CI: 1.17–2.92). There were insufficient data to pool results for association between urogenital schistosomiasis and HIV infection in the males. Conclusion: Our investigation supports the hypothesis of an association between urogenital schistosomiasis with HIV/AIDS infection in females. Due to insufficient evidence, no conclusion could be drawn in males with urogenital schistosomiasis. Large-scale prospective studies are needed in future. Author summary: Urogenital schistosomiasis, caused by parasitic trematode Schistosoma haematobium is a significant source of morbidity in sub Saharan Africa. HIV infection caused by a retrovirus is of two subtypes HIV 1 and HIV 2, with subtype HIV 1 being found worldwide and more aggressive, leading to HIV/AIDS. Research on both of these diseases in the same settings, has shown that these diseases cross paths. This has led to the suggestion that there could be a possible association between the two. Here we describe a systematic review that was carried out to determine if there is an association between UGS and HIV/AIDS infections. We searched all published articles available in MEDLINE, EMBASE, Global Health (CABI), and Global Index Medicus before 28th January 2020. We found eight observational studies eligible to be included in the systematic review and no intervention study. Six of these studies were included in the meta-analysis. A summarized meta-analysis of the study findings with adjusted OR showed that there was a likely association between urogenital schistosomiasis and HIV/AIDS infections in females. However, due to limited papers in males, no conclusion could be drawn. [ABSTRACT FROM AUTHOR]

Over the last three decades, 35 million people have died of AIDS. As a result, HIV/AIDS has brought about a significant reduction in human capital, especially in sub‐Saharan Africa. Several studies have examined the effects of HIV/AIDS on human capital, in particular educational attainment. These studies have examined different countries, datasets, and educational outcomes. This systematic literature review provides a comprehensive up‐to‐date overview of peer‐reviewed papers published in English by focusing on the main mechanisms that influence the effects of HIV/AIDS on educational outcomes. These are sickness of the child, orphanhood, and sickness of parents. The results show that educational outcomes of HIV‐infected children, AIDS orphans, and children with HIV‐infected parents are affected differently. HIV‐infected children mainly miss school days due to illness and medical appointments, and orphans mainly face financial problems and lack motivation in their education, while children with HIV‐infected parents may have to take care of their sick parents or face financial problems that affect their education. Distinguishing these groups of children could help to formulate policies that adequately improve schooling outcomes of these vulnerable children. [ABSTRACT FROM AUTHOR]

This paper examines the effect of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) on economic growth in sub-Saharan Africa (SSA) using data from 46 SSA countries spanning the period 2000–2015. Results based on the system-generalized method of moments estimation showed that a 1% increase in the HIV/AIDS prevalence rate in SSA decreased the growth in per capita income by 0.47%. The impact of HIV/AIDS on economic growth was felt most in Eastern Africa followed by West Africa, although the prevalence rate was highest in Southern Africa. In particular, a 1% increase in the prevalence rate of HIV/AIDS in Eastern Africa and West Africa retarded growth in per capita income by 0.64% and 0.47%, respectively, over the study period. The paper suggests that for SSA to minimize the impact of HIV/AIDS prevalence on growth, African governments should take a cue from the southern African countries by making anti-retroviral drugs more accessible and affordable to persons living with the disease. [ABSTRACT FROM AUTHOR]

Background: Lack of dependable morbidity and mortality data complicates efforts to measure the demographic or population-level impact of the global HIV/AIDS epidemic. Mortuary-based mortality surveillance can address gaps in vital statistics in low-resource settings by improving accuracy of measuring HIV-associated mortality and indicators of access to treatment services among decedents. This paper describes the process and considerations taken in conducting mortuary and hospital-based HIV mortality surveillance among decedents in Kenya.Main Text: We conducted HIV mortuary and hospital-based mortality surveillance at two of the largest mortuaries in Kisumu County, Kenya (April 16-July 12, 2019). Medical charts were reviewed for documentation of HIV status among eligible decedents. HIV testing was done on blood and oral fluid samples from decedents with undocumented HIV status and those whose medical records indicated HIV-negative test results > 3 months before death. A panel of experts established the cause of death according to the International Classification of Diseases, 10th Revision rules. Civil registry data for the year 2017 were abstracted and coded to corresponding ICD-10 codes. Of the 1004 decedents admitted to the two mortuaries during the study period, 49 (4.9%) were unavailable because they had been transferred to other facilities or dispatched for burial before enrolment. Of the 955 available decedents, 104 (10.9%) were ineligible for the study. Blood samples were collected from 659 (77.4%) decedents, and 654 (99.2%) were tested for HIV. Of the 564 decedents eligible for the OraQuick® validation sub-study, 154 were eligible for oral sample collection, and 132 (85.7%) matched pre- and post-embalming oral samples were collected and tested. Of the 851 eligible decedents, 241 (28.3%) had evidence of HIV infection: 119 had a diagnosis of HIV infection recorded in their patient files, and 122 had serological evidence of HIV infection.Conclusion: This study shows that in low-resource settings, conducting hospital and mortuary-based surveillance is feasible and can be an alternative source of mortality data when civil registry data are inadequate. [ABSTRACT FROM AUTHOR]

With the growing number of older people living with HIV, "What is the most effective geriatric care and the research trend of existing literature?" is a compelling question after 30 years since the first paper related to aging and HIV/AIDS published. Our study aims to apply quantitative and qualitative analysis to explore the knowledge gaps and describes the research interest of gerontology research in the field of HIV. A bibliometric analysis was conducted based on the databased of the Web of Science from 1991 to 2019. The major domains of research areas were visualized by using VOSviewer software. Latent Dirichlet Allocation (LDA) was applied to classify the dataset into topics. There was a rising number of publications about this topic over time. Our findings indicated that antiretroviral treatment and evaluating quality of life and harm reduction were the major domains regarding care for OPLWH. In addition, the finding highlights the role of social competence in treatment outcomes. Further research needs to tailor multi-disciplinary programs and flexible interventions to reduce the burden and the mortality rate of HIV/AIDS. [ABSTRACT FROM AUTHOR]

Purpose: The present study aimed to assess the current situation of Chinese dental bachelor interns on HIV/AIDS-related knowledge and their attitudes towards HIV/AIDS patients.Materials and Methods: A cross-sectional, paper-based survey involving 147 dental students from three Chinese dental schools was conducted. Students were recruited to complete the questionnaire regarding their knowledge, awareness and attitudes concerning HIV/AIDS anonymously and voluntarily.Results: A total of 144 students responded to the study, generating a response rate of 98.0%. Although 97.0% of the dental students believed dentists were at high risk of HIV infection, 97.2% of students expressed no prejudice towards HIV/AIDS patients and stated their willingness to provide oral healthcare service for such patients. No statistically significant differences in the responses on attitudes and some basic knowledge were found between students who had received the relevant education about infection control and the students who had not. However, regarding most questions about oral manifestations in adult and paediatric patients living with AIDS, the students who received relevant education showed more knowledge than the students who did not (p <0.05). The cognitive level about respecting HIV/AIDS patients' autonomy and privacy was generally low in all the students.Conclusions: Most of the dental students in this survey held positive attitudes towards HIV/AIDS patients and good grasp of some basic knowledge about HIV/AIDS. On the other hand, the questionnaire results reflected gaps in education, such as respecting HIV/AIDS patients' privacy. [ABSTRACT FROM AUTHOR]

AIDS is a chronic infectious disease that has been having a major impact on human health and social stability. In this paper, based on the deterministic SIATR model, a stochastic SIATR model is developed to account for the spread of AIDS by introducing the Ornstein–Uhlenbeck process. First, the existence and uniqueness of the global positive solution of the model are investigated. Second, a threshold R0E is set: when R0E < 1, the disease will become extinct; when R0E > 1, the disease will persist. Then, it is shown that there exists a stationary distribution for the model when R0E > 1. On this basis, we derive the exact expression for the probability density function of the model in the neighborhood of the quasi-equilibrium state. Finally, the results of the previous proof are verified by several numerical simulations. [ABSTRACT FROM AUTHOR]

Reverse transcriptase (RT) and integrase (IN) are two pivotal enzymes in HIV-1 replication. RT converts the single-stranded viral RNA genome into double-stranded DNA and IN catalyzes the integration of viral double-stranded DNA into host DNA. Currently, dual inhibitors of HIV-1 RT and IN have become a hotspot in new anti-HIV drug research and development. A dual inhibitor of HIV-1 RT/IN does the same thing as the two independent drugs would do. In this paper, we develop a mathematical model comprising a system of nonlinear differential equations describing HIV-1 RT/IN catalyzed biochemical reactions based on Michaelis–Menten enzyme kinetic reaction. In the formulated model we incorporate HIV-1 RT/IN dual inhibitor which simultaneously works as a non-nucleoside RT inhibitor and IN inhibitor. To examine the efficacy of HIV-1 RT/IN dual inhibitor in the treatment of HIV-1 infection, we have introduced a one-dimensional impulsive differential equation model and determined an effective dosing regimen for applying the inhibitor numerically. Furthermore, the exact closed form solution of the impulsive differential equation model is carried out by using the Lambert W function and the local stability of the periodic solution is also obtained analytically. The results obtained from analytical as well as numerical studies provide a basic idea to investigate the minimum dose with the highest efficacy for administering HIV-1 RT/IN dual inhibitors to prevent HIV-1 infection. [ABSTRACT FROM AUTHOR]

Human immunodeficiency virus (HIV) is a serious disease that threatens and affects capital stock, population composition, and economic growth. This research paper aims to study the mathematical modeling and disease dynamics of HIV/acquired immunodeficiency syndrome (AIDS) with memory effect. We propose two fractional models in the Caputo sense for HIV/AIDS with and without migration. First, we prove the existence and positivity of both models and calculate the basic reproduction number R0$$ {\mathcal{R}}_0 $$ using the next generation method. Then, we study the local and global stability of the obtained equilibria. In addition, numerical simulations are provided for different values of the fractional order ρ$$ \rho $$ using the Adams–Bashforth–Moulton fractional scheme, to verify the theoretical results. Moreover, a sensitivity analysis of the parameters for the model with migration is carried out. [ABSTRACT FROM AUTHOR]

Copyright of Revista Estudos Feministas is the property of Revista Estudos Feministas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Ending the HIV/AIDS pandemic is among the sustainable development goals for the next decade. To overcome the problem caused by the imbalances between the need for care and the limited resources, we shall improve our understanding of the local HIV epidemics, especially for key populations at high risk of HIV infection. However, HIV prevalence rates for key populations have been difficult to estimate because their HIV surveillance data are very scarce. This paper develops a multivariate spatial model for predicting unknown HIV prevalence rates among key populations. The proposed multivariate conditional auto-regressive model efficiently pools information from neighbouring locations and correlated populations. As the real data analysis illustrates, it provides more accurate predictions than independently fitting the sub-epidemic for each key population. Furthermore, we investigate how different pieces of surveillance data contribute to the prediction and offer practical suggestions for epidemic data collection. [ABSTRACT FROM AUTHOR]

This audit aimed to measure the impact of introducing and then modifying an electronic patient record (EPR) system on the uptake of HIV testing at a level 3 genitourinary medicine service. It was a retrospective case note review of all new and rebook patients attending our service in 2007 (paper records) and 2010 (EPR), and a prospective review in 2012 (following modification of the EPR). The uptake of HIV testing increased significantly from 72.8% to 78.1% following introduction of the EPR (p = 0.009), and increased further to 86.6% (p < 0.0001) following modification of the EPR. Clinics using paper notes should consider switching to EPR as a means of increasing HIV testing uptake. [ABSTRACT FROM PUBLISHER]

Emerging infectious diseases draw critical attention to the human–animal interface for understanding and explaining global health crises. These include zoonoses that directly affect human health, as well as epizootic events in livestock and wildlife rendering economic and societal systems vulnerable. This paper traces the overlaps between three viral trajectories – that of African Swine Fever (ASF), AIDS, and COVID-19 – to show how technoscientific ways of knowing and responding to disease outbreaks frame certain forms of human–animal contact as risky and dangerous. We mobilize the notion of a reservoir, understood both as (surplus) bodies harboring infectious disease, and an epistemic pool of associations and response protocols accompanying health crises. Our point of departure is a short-lived hypothesis from the 1980s on the connection between AIDS and ASF, which marshalled racialized fears over undesirable interspecies contact. From there we inspect the tension between the epistemic and affective modes of causality in current and historical narratives, which seek the blame for disease in transgressions against nature. By focusing on how disease narratives spill over to social categories of race and class, our analysis questions the depictions of these transgressions from the standpoint of universal humanity. [ABSTRACT FROM AUTHOR]

Black women in the United States continue to be disproportionately affected by the Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) epidemic. HIV/AIDS activism among Black women for Black women may be one solution to reduce the disparate rates of HIV/AIDS among Black women. However, little is known about what processes and experiences prompt Black women to participate in HIV/AIDS activism. In this paper, I aim to identify mechanisms of empowerment for Black women to engage in HIV/AIDS activism. I draw upon empowerment theory as a theoretical framework to guide analysis of the literature and to offer a strengths‐based perspective on Black women's efforts to reduce the spread of HIV/AIDS. An extensive literature search was conducted to identify studies of Black women's participation in HIV/AIDS activism. The search yielded 11 studies that were included for review. Synthesis of the literature indicated the following analytic themes as mechanisms of empowerment for Black women to participate in HIV/AIDS activism: relationships and interactions with others, critical awareness, self‐reflection, and spirituality. Article limitations, suggestions for future research, and implications for social change are also discussed. Overall, findings from this study suggest that there are unique mechanisms that facilitate psychological empowerment and prompt Black women's entry into HIV/AIDS activism. Highlights: A comprehensive review of 11 articles on Black women's participation in Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) activism. Explores how Black women become psychologically empowered to become HIV/AIDS activists. Many mechanisms of empowerment for Black women engaged in HIV/AIDS activism are communal. Emphasizes psychological empowerment as not only an intrapsychic process. [ABSTRACT FROM AUTHOR]

Copyright of Médecine is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction The HIV/AIDS prevention program among pregnant mothers aims to reduce the risk of HIV transmission from mother to baby. It also aims to reduce stigma and discrimination, as well as deaths due to HIV/AIDS. This paper aimed to find out obstacles that occur in the implementation of HIV/AIDS transmission program in Indonesia. Methods Online literature search was done on Google Scholar, Science Direct and PubMed databases with the keywords related to “HIV/AIDS” and transmission prevention program among mothers to children. The search resulted in a total of 343 articles. Results After the abstracts were reviewed, there were only 16 articles selected. Conclusions The implementation of the program in Indonesia has been run but is not yet optimal because of several obstacles i.e., the insufficient number of health workers and poor knowledge of health workers. Figuring out solutions to the obstacles could ease the program implementation to reduce the cases of HIV/AIDS. Obstacles were found in the implementation of the HIV/AIDS prevention program among mothers and children in Indonesia. [ABSTRACT FROM AUTHOR]

In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD) mortality and morbidity. Hypertension is characterised by elevated blood pressure (BP) ≥ 140/90 mmHg. Current hypertension guidelines recommend the use of antihypertensives belonging to the following classes: calcium channel blockers (CCB), angiotensin converting inhibitors (ACEI), angiotensin receptor blockers (ARB), diuretics, β-blockers, and mineralocorticoid receptor antagonists (MRAs), to manage hypertension. Still, a considerable number of hypertensives in Africa have their BP uncontrolled due to poor drug response and remain at the risk of CVD events. Genetic factors are a major contributing factor, accounting for 20% to 80% of individual variability in therapy and poor response. Poor response to antihypertensive drug therapy is characterised by elevated BPs and occurrence of adverse drug reactions (ADRs). As a result, there have been numerous studies which have examined the role of genetic variation and its influence on antihypertensive drug response. These studies are predominantly carried out in non-African populations, including Europeans and Asians, with few or no Africans participating. It is important to note that the greatest genetic diversity is observed in African populations as well as the highest prevalence of hypertension. As a result, this warrants a need to focus on how genetic variation affects response to therapeutic interventions used to manage hypertension in African populations. In this paper, we discuss the implications of genetic diversity in CYP11B2, GRK4, NEDD4L, NPPA, SCNN1B, UMOD, CYP411, WNK, CYP3A4/5, ACE, ADBR1/2, GNB3, NOS3, B2, BEST3, SLC25A31, LRRC15 genes, and chromosome 12q loci on hypertension susceptibility and response to antihypertensive therapy. We show that African populations are poorly explored genetically, and for the few characterised genes, they exhibit qualitative and quantitative differences in the profile of pharmacogene variants when compared to other ethnic groups. We conclude by proposing prioritization of pharmacogenetics research in Africa and possible adoption of pharmacogenetic-guided therapies for hypertension in African patients. Finally, we outline the implications, challenges, and opportunities these studies present for populations of non-European descent. [ABSTRACT FROM AUTHOR]

There are numerous contagious diseases caused by pathogenic microorganisms, including bacteria, viruses, fungi, and parasites, that have the propensity to culminate in fatal consequences. A communicable disease is an illness caused by a contagion agent or its toxins and spread directly or indirectly to a susceptible animal or human host by an infected person, animal, vector, or immaterial environment. Human immunodeficiency virus (HIV) infection, hepatitis A, B, and C, and measles are all examples of communicable diseases. Acquired immunodeficiency syndrome (AIDS) is a communicable disease caused by HIV infection that has become the most severe issue facing humanity. The research work in this paper is to numerically explore a mathematical model and demonstrate the dynamics of HIV/AIDS disease transmission using a continuous Galerkin–Petrov time discretization of a higher-order scheme, specifically the cGP(2)-scheme. Depict a graphical and tabular comparison between the outcomes of the mentioned scheme and those obtained through other classical schemes that exist in the literature. Further, a comparison is performed relative to the well-known fourth-order Ruge–Kutta (RK4) method with different step sizes. By contrast, the suggested approach provided more accurate results with a larger step size than RK4 with a smaller step size. After validation and confirmation of the suggested scheme and code, we implement the method to the extended model by introducing a treatment rate and show the impact of various non-linear source terms for the generation of new cells. We also determined the basic reproduction number and use the Routh-Hurwitz criterion to assess the stability of disease-free and unique endemic equilibrium states of the HIV model. [ABSTRACT FROM AUTHOR]

HIV/AIDS and COVID-19 co-infection is a common global health and socio-economic problem. In this paper, a mathematical model for the transmission dynamics of HIV/AIDS and COVID-19 co-infection that incorporates protection and treatment for the infected (and infectious) groups is formulated and analyzed. Firstly, we proved the non-negativity and boundedness of the co-infection model solutions, analyzed the single infection models steady states, calculated the basic reproduction numbers using next generation matrix approach and then investigated the existence and local stabilities of equilibriums using Routh-Hurwiz stability criteria. Then using the Center Manifold criteria to investigate the proposed model exhibited the phenomenon of backward bifurcation whenever its effective reproduction number is less than unity. Secondly, we incorporate time dependent optimal control strategies, using Pontryagin's Maximum Principle to derive necessary conditions for the optimal control of the disease. Finally, we carried out numerical simulations for both the deterministic model and the model incorporating optimal controls and we found the results that the model solutions are converging to the model endemic equilibrium point whenever the model effective reproduction number is greater than unity, and also from numerical simulations of the optimal control problem applying the combinations of all the possible protection and treatment strategies together is the most effective strategy to drastically minimizing the transmission of the HIV/AIDS and COVID-19 co-infection in the community under consideration of the study. [ABSTRACT FROM AUTHOR]

The human immunodeficiency viruses are two species of Lentivirus that infect humans. Over time, they cause acquired immunodeficiency syndrome, a condition in which progressive immune system failure allows life-threatening opportunistic infections and cancers to thrive. Human immunodeficiency virus infection came from a type of chimpanzee in Central Africa. Studies show that immunodeficiency viruses may have jumped from chimpanzees to humans as far back as the late 1800s. Over decades, human immunodeficiency viruses slowly spread across Africa and later into other parts of the world. The Susceptible-Infected-Recovered (SIR) models are significant in studying disease dynamics. In this paper, we have studied the effect of irresponsible immigrants on HIV/AIDS dynamics by formulating and considering different methods. Euler, Runge Kutta, and a Non-standard finite difference (NSFD) method are developed for the same problem. Numerical experiments are performed at disease-free and endemic equilibria points at different time step sizes 'h'. The results reveal that, unlike Euler and Runge Kutta, which fail for large time step sizes, the proposed Non-standard finite difference (NSFD) method gives a convergence solution for any time step size. Our proposed numerical method is bounded, dynamically consistent, and preserves the positivity of the continuous solution, which are essential requirements when modeling a prevalent disease. [ABSTRACT FROM AUTHOR]

Mobile payment services have been widely applied in our daily life, where users can conduct transactions in a convenient way. However, critical privacy concerns have arisen. Specifically, a risk of participating in a transaction is the disclosure of personal privacy. This might occur if, for example, the user pays for some special medicine, such as AIDS medicine or contraceptives. In this paper, we propose a mobile payment protocol that is suitable for mobile devices only with limited computing resources. In particular, the user in a transaction can confirm the identity of others in the same transaction while the user cannot show convincing evidence to prove that others also take part in the same transactions. We implement the proposed protocol and test its computation overhead. The experiment results corroborate that the proposed protocol is suitable for mobile devices with limited computing resources. [ABSTRACT FROM AUTHOR]

This paper explores the vertices of Jung's, Anzaldúa's and Benjamin's distinct ontologies and the way in which they connect in the shared recognition that what has been estranged in human history is enigmatically lodged in the world's fabric today. Cultural distress, in other words, is the outcome of what has become repudiated in the self and the collective across time. From this perspective, the paper argues that we have a collective responsibility to listen to the claims of the dead laid bare in moments of contemporary real‐world danger and it elaborates the psychical dimensions of being that are cultivated in times of danger. The author contends that these psychical presences are the dead of human history including our ancestral heritage that linger and possibly may penetrate our awareness. They haunt and hold a potential to animate our movement towards a sublimatory process that can be seen as a precursor to social responsiveness and action. The author explores this through her own experience with an example of the spawning of spiritual activism within the socio‐political maelstrom of AIDS. [ABSTRACT FROM AUTHOR]

The AIDS pandemic disproportionately affects Canadian gay men, women, racialized communities, people who inject drugs, and people who have been or are incarcerated, leading these groups to engage in coalitional activism to advance HIV/AIDS prevention and treatment. This paper examines how the effects of AIDS necessitated a response across these marginalized groups. Oral history interviews conducted in Toronto by the Canadian AIDS Activist History Project were examined to discuss the coalitions that were formed amongst marginalized groups in Toronto during the height of the Canadian AIDS crisis of the 1980s and 1990s. Oral history interviews are incredibly valuable to marginalized communities; yet, once they are collected, they are often left unanalyzed. This paper analyzes existing oral history interviews to provide an overview of some of the tensions and successes between activists who belonged to different social groups. The paper ends with a discussion of intersectionality and the role of systemic activism in Canadian AIDS activist history. [ABSTRACT FROM AUTHOR]

This paper discusses Gilbert Cole's book, "Infecting the Treatment: Being an HIV-Positive Analyst." The author provides some personal reflections on the outbreak of AIDS and the impact it had upon his work as a psychotherapist. The paper addresses the importance of the cognitive schemata Cole provides to psychotherapists working with seropositive patients. This paper then addresses a powerful technique, a therapist's self disclosure to a patient, upon which Cole's work focuses. Using the example of psychoanalytic strictures regarding self-disclosure, the author argues that self-disclosure is more likely to be adhered to in theory than it is in practice. The author agrees with Cole that non-disclosure is often a technique used by analysts to hide, rather than provide a therapeutic field of action. The specific case of therapists hiding their antihomosexuality when working with lesbians and gay men is used to illustrate the author's perspective. A specific case presented by Cole in his book is then used to both compare and contrast Cole and this paper's author's use of self-disclosure. The paper commends Cole's study for opening a debate on how to use countertransference and self-disclosure as tools which widen and enrich the therapeutic relationship. [ABSTRACT FROM AUTHOR]

Copyright of AIDS & Behavior is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Category emergence has been a central question in organization theory. Yet, we still do not understand what drives category persistence and updating during emergence as new information arises. We investigate this question through a rich set of oral histories and archival materials on the emergence of the category AIDS from 1978 to 1985. We show that the initial proto-category's features and causal theories cohered with its stigmatized moral meanings. Over time, anomalies challenging these features and theories spurred a minority of medical professionals to update the category's causal theory. However, a silent majority resisted updating the category because the new causal theory conflicted with the proto-category's moral meanings, challenging the clear moral boundary dividing what was perceived as worthy from what was perceived as unworthy. As a result, the majority silenced the vocal minority's updated understandings and withheld resources from the category. This article contributes to the literature on categorization by showing that conflicts between category dimensions can stifle updating, amplify imprinting, and prolong category persistence. Particularly, the dichotomous nature of the moral dimension might hinder the updating of other dimensions, such as the causal one, despite accumulated evidence suggesting the need for updates. We show that calls for category updating backed solely by rational arguments may fail to persuade the silent majority and may falter until the moral boundary is punctured and the category is morally reappraised. [ABSTRACT FROM AUTHOR]

Globally, women represent more than half the people living with HIV. This proportion varies by country, with an over-representation of HIV among men who have sex with men (MSM) in some regions. For example, in Australia, MSM account for over 60% of transmissions, with heterosexual sex accounting for almost a quarter of transmissions. Irrespective of geographic region, there is evidence that women can have a different lived experience of HIV due to their unequal social and economic status in society, while MSM can have a different lived experience depending on the laws and customs of their geographic location. Gender differences related to risk factors, stigma, access to services, mental health, health-related quality of life and economic consequences have been consistently reported globally. This paper explores the subjective lived experience of gender and sexuality disparities among three individuals living with HIV in Australia: a male who identified as gay, and a male and female who each identified as heterosexual. Analysis of themes from these three case reports indicated discernible differences by gender and sexuality in four areas: access to medical services, social support, stigma and mental health. It is argued that knowledge and understanding of potential gender and sexuality disparities must be factored into supportive interventions for people living with HIV in Australia. [ABSTRACT FROM AUTHOR]

In this paper, we mainly present the dynamic properties of a stochastic SICA model with general incidence rate. Through rigorous analysis and reasoning of the stochastic model, we obtain that the solution of the model is global, positive, and unique. By constructing the threshold value R0s$$ {R}_0^s $$, which includes the influence of white noise, we obtain a sufficient condition for the ergodicity of this model. Furthermore, we show that the model has a unique ergodic stationary distribution while R0s>1$$ {R}_0^s>1 $$ by adopting a novel method. The extinction of the system is also established. Besides, the expression of probability density function of the stochastic model with bilinear incidence rate around the unique stable positive equilibrium of the deterministic model is derived. Finally, numerical simulations are presented to illustrate the theoretical results. [ABSTRACT FROM AUTHOR]

The accurate diagnosis of pulmonary cryptococcosis (PC) is an important guarantee for the selection of reasonable treatment methods. In this paper, the clinical and imaging manifestations of PC in non-AIDS patients were retrospectively analyzed, and according to whether there was an underlying disease, a comparative analysis was carried out to deepen the understanding of PC, and improve the accuracy of its diagnosis. Both clinical and CT imaging data of 118 PC patients were analyzed retrospectively. The clinical manifestations of PC patients were not specific, and 61 patients had no apparent symptoms. A total of 49 patients (49/118) were treated with antifungal agents alone, 46 of them had follow-up records after treatment, and 91.3% (42/46) of them achieved a good outcome. The most common imaging sign was the subpleural nodule or mass. Other main imaging signs include bronchial air sign (50/118), halo sign (32/118), ring target sign (65/118), lobulation sign (72/118), and necrosis (76/118). In terms of age, halo sign, and ring target sign, there were significant differences between the group with underlying disease and the group without underlying disease (P  < .05). The CT manifestations of PC have some characteristics, and using antifungal agents can achieve good outcomes. [ABSTRACT FROM AUTHOR]

Objectives: With the prolongation of life span and increasing incidence of comorbidities, polypharmacy has become a challenge for people living with HIV/AIDS (PLWH). This review aimed to identify barriers and facilitators to maintaining a high level of polypharmacy adherence in people living with HIV/AIDS. Methods: Nine electronic databases were searched for studies from 1996 to October 2021. Studies were included if they were conducted with adults living with HIV/AIDS and reported barriers and facilitators to maintaining a high level of polypharmacy adherence. This review presents a conceptual framework model to help understand the barriers and facilitators. Results: Twenty-nine studies were included. The majority of publications were observational studies. Eighty specific factors were identified and further divided into five categories, including individual factors, treatment-related factors, condition-related factors, healthcare provider-related factors, and socioeconomic factors, based on the multidimensional adherence model (MAM). Conclusion: Eighty factors associated with polypharmacy adherence among people living with HIV/AIDS were identified and grouped into five major categories. Healthcare providers can make decisions based on the five categories of relevant factors described in this paper when developing interventions to enhance polypharmacy adherence. It is recommended that medications be evaluated separately and that an overall medication evaluation be conducted at the same time to prevent inappropriate polypharmacy use. [ABSTRACT FROM AUTHOR]

Human Immunodeficiency virus (HIV) and its clinical entity, the Acquired Immunodeficiency Syndrome (AIDS) continue to represent an important health burden worldwide. Although great advances have been made towards determining the way viral genetic diversity affects clinical outcome, genetic association studies have been hindered by the complexity of their interactions with the human host. This study provides an innovative approach for the identification and analysis of epidemiological associations between HIV Viral Infectivity Factor (Vif) protein mutations and four clinical endpoints (Viral load and CD4 T cell numbers at time of both clinical debut and on historical follow-up of patients. Furthermore, this study highlights an alternative approach to the analysis of imbalanced datasets, where patients without specific mutations outnumber those with mutations. Imbalanced datasets are still a challenge hindering the development of classification algorithms through machine learning. This research deals with Decision Trees, Naïve Bayes (NB), Support Vector Machines (SVMs), and Artificial Neural Networks (ANNs). This paper proposes a new methodology considering an undersampling approach to deal with imbalanced datasets and introduces two novel and differing approaches (MAREV-1 and MAREV-2). As theses approaches do not involve human pre-determined and hypothesis-driven combinations of motifs having functional or clinical relevance, they provide a unique opportunity to discover novel complex motif combinations of interest. Moreover, the motif combinations found can be analyzed through traditional statistical approaches avoiding statistical corrections for multiple tests. [ABSTRACT FROM AUTHOR]

Death is inevitable and universal, and the corona virus disease has only further intensified a world of uncertainties as a result of frequent accidents, HIV/AIDS, cancer and natural disasters. Bereavement after any death is a potentially disruptive life event with consequences in physical and mental health, relationships and social functioning. Death is a rather odd, thought-provoking and challenging experience, particularly in the lives of children and adolescents. Death of parent/s, sibling, relative/s, teacher, classmate or friend is a relatively new and challenging phenomenon. Persons working with pupils and students, including teachers, counsellors, school chaplain and social workers, need to be prepared to offer help to those who experience bereavement. Death is unpredictable and may occur naturally, suddenly, or traumatically. In several instances, help is sometimes required in advance of bereavement in that the death may be anticipated such as instances of prolonged illness or following a fatal accident. In all cases, the role of the teacher and counsellor in the school is pivotal in supporting pupils and students who have been bereaved. This paper highlights the need to impart post-traumatic growth in bereft pupils and students in schools in order to cope with bereavement. [ABSTRACT FROM AUTHOR]

The human immunodeficiency virus (HIV) is a major global public health issue and causes millions of deaths around the globe. The most severe phase of HIV infection is known as AIDS. In recent years, a number of mathematical models based on classical integer-order derivative have been developed to analyze the insight dynamics of HIV/AIDS. This paper presents the transmission dynamics of HIV/AIDS using fractional order (FO) and a fractal-fractional order compartmental model with the power-law kernel. In the first phase, the proposed model is formulated using the Caputo-type fractional derivative. The basic properties such as the solution positivity and existence as well as uniqueness of the fractional model are presented. The equilibria and the basic reproductive number ℛ 0 are evaluated. Further, using fractional stability concepts the stability of the model (both local and global) around the equilibrium is presented in the disease-free case. In addition, the fractional model is solved numerically, and the graphical results with many values of q 1 are shown. In the second phase, the concept of a fractal-fractional (FF) operator is applied to obtain a more generalized model that addresses the dynamics of HIV/AIDS. The uniqueness and existence of the solutions of the FF-based model are shown via the Picard–Lindelof approach while the modified Adams–Bashforth method is utilized to present the numerical solution. Detailed numerical simulations are presented for various values fractional as well as the fractal orders, q 1 and q 2 , respectively. The graphical results reveal that the FF-based model provides biologically more feasible results than the models in fractional and classical integer-order cases. [ABSTRACT FROM AUTHOR]

This review examines the nexus of poverty, malnutrition and diseases in Africa, the challenges, implications and their mitigation. The paper takes a critical look at available literatures on the primary causes, modes, implications and solutions to the problems of poverty, malnutrition and diseases in Africa continent. Poverty and malnutrition are outcomes of uncontrolled rapid population growth, inefficient agricultural and industrial practices, high debt profile of many African countries due to poor governance and corruption, diseases such as AIDS epidemic, malaria, Ebola virus and COVID-19 pandemic, poor and inadequate health infrastructure and armed conflicts. African poverty scenario entails non-availability of basic human needs which makes many Africans to be very poor. Despite abundance of natural resources, the gross domestic product per capita of many African countries is among the lowest of list of nations of the world. According United Nation in 2009, 22 of 24 nations among the "Low Human Development" nations of the world on the UN's Human Development Index were found in sub-Saharan Africa. Out of the 50 countries on the United Nation list of least developed countries, 34 of them were in Africa. According to FAO data over 200 million people in sub-Saharan Africa were undernourished in 2014-2016. The prevalence of undernourishment in sub-Saharan Africa rose from 181 million in 2010 to 222 million in 2016. In 2016, Africa had the highest prevalence of undernourishment in the world and estimated to be 20% of the population. While this was alarming in Eastern Africa where one-third of the population is suspected to be undernourished. In a similar data, World Bank also found that sub-Saharan Africa Poverty and Equity Data was 47% with over 500 million people in abject poverty in 2012. Poverty is the major cause of hunger and malnutrition in Africa while hunger and malnutrition escalated the problem of diseases in African continent. Poverty has continued to torment Africa as a result of poor and harmful economic policies, conflict and war, environmental factors like drought and climate change and population growth, poor leadership and greed. With the advent of COVID-19, the problem of poverty, malnutrition and diseases has been escalated and in many African countries people find it difficult to make ends meet. [ABSTRACT FROM AUTHOR]

Introduction: The COVID-19 epidemic and various control and mitigation measures to combat the widespread outbreak of the disease may affect other parts of health care systems. There is a concern that the COVID-19 pandemic could disrupt HIV services. Therefore, this study aimed to systematically evaluate the effect of the COVID-19 pandemic on service delivery and treatment outcomes in people with HIV. Methods: In this study, a systematic search was conducted using the keywords in the online databases including Scopus, PubMed, Web of Science, and Cochrane databases. The retrieved articles underwent a two-step title/abstract and full-text review process, and the eligible papers were selected and included in the qualitative synthesis. Result: We selected 16 studies out of 529 retrieved records that met the inclusion criteria for this review. Study populations of the selected studies were either HIV-positive patients or HIV clinics and healthcare providers. Most studies were focused on adhering to and obtaining medication and attending clinical appointments and their decrement during the pandemic. Other aspects of HIV care (alternative healthcare settings, viral suppression, psychological care, etc.) were discussed to a lesser extent by the included studies. Conclusion: Interruption in in-person visits and medical follow-up services, loss of adherence to treatment, and subsequent increase in mortality due to the COVID-19 pandemic complications in PLHIV have led to growing concerns. Other challenges were psychological disorders such as anxiety and depression, an increase in substance abuse, and a rise in experienced stigma and discrimination. However, the use of telemedicine in some countries helps to alleviate the situation to some extent and is recommended in similar settings in the future. [ABSTRACT FROM AUTHOR]

This paper highlights experiences and perceptions of older gay males living with Human Immunodeficiency Virus (HIV) in relation to age, sexual orientation, HIV status and how they perceive health. Participants were gay males aged 50 and over living in England, diagnosed with HIV for longer than 2 years. In total, 19 interviews were conducted between March 2020 and March 2021. Data were analysed using thematic analysis. Three major themes were generated: 1.) Health as holistic and as a balance; 2.) The impact of HIV on people's lives; 3.) The Intersectionality of stigma: a lifetime of discrimination. Participants highlighted the changing nature of the concept of health through their lifespan while the intersectionality of stigma in different contexts is examined considering the personal journey of living with HIV. The implications of health as a complex concept and intersectional stigma on the planning and delivering of care in this population are discussed. [ABSTRACT FROM AUTHOR]