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Your search keyword '"Xing, Fu-Guo"' showing total 2 results
Start Over Author "Xing, Fu-Guo" Topic agriculture (general)
2 results on '"Xing, Fu-Guo"'

1. Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens

Author

Xian-ying ZENG, Xiao-han CHEN, Shu-jie MA, Jiao-jiao WU, Hong-mei BAO, Shu-xin PAN, Yan-jing LIU, Guo-hua DENG, Jian-zhong SHI, Pu-cheng CHEN, Yong-ping JIANG, Yan-bing LI, Jing-lei HU, Tong LU, Sheng-gang MAO, Xing-fu GUO, Jing-li LIU, Guo-bin TIAN, and Hua-lan CHEN

Subjects
avian influenza, H5/H7 trivalent vaccine, Re-11, Re-12 and H7-Re2 strains, protective efficacy, Agriculture (General), S1-972
Abstract

We developed an H5/H7 trivalent inactivated vaccine by using Re-11, Re-12, and H7-Re2 vaccine seed viruses, which were generated by reverse genetics and derived their HA genes from A/duck/Guizhou/S4184/2017(H5N6) (DK/GZ/S4184/17) (a clade 2.3.4.4d virus), A/chicken/Liaoning/SD007/2017(H5N1) (CK/LN/SD007/17) (a clade 2.3.2.1d virus), and A/chicken/Guangxi/SD098/2017(H7N9) (CK/GX/SD098/17), respectively. The protective efficacy of this novel vaccine and that of the recently used H5/H7 bivalent inactivated vaccine against different H5 and H7N9 viruses was evaluated in chickens. We found that the H5/H7 bivalent vaccine provided solid protection against the H7N9 virus CK/GX/SD098/17, but only 50–60% protection against different H5 viruses. In contrast, the novel H5/H7 trivalent vaccine provided complete protection against the H5 and H7 viruses tested. Our study underscores the importance of timely updating of vaccines for avian influenza control.

Published
2020
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2. Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens

Author

Hualan Chen, Tong Lu, Yan-bing Li, Hongmei Bao, Xianying Zeng, Jing-lei Hu, Xing-fu Guo, Yongping Jiang, Guohua Deng, Shuxin Pan, Pucheng Chen, Jiao-jiao Wu, Guobin Tian, Jianzhong Shi, Jing-li Liu, Sheng-gang Mao, Xiao-han Chen, Yanjing Liu, and Shu-jie Ma

Subjects
0106 biological sciences, Agriculture (General), Plant Science, Biology, medicine.disease_cause, 01 natural sciences, Biochemistry, Bivalent (genetics), Virus, S1-972, Re-11, Food Animals, medicine, H5/H7 trivalent vaccine, protective efficacy, Gene, Ecology, 04 agricultural and veterinary sciences, Virology, Influenza A virus subtype H5N1, Reverse genetics, Re-12 and H7-Re2 strains, Inactivated vaccine, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Animal Science and Zoology, avian influenza, Agronomy and Crop Science, 010606 plant biology & botany, Food Science
Abstract

We developed an H5/H7 trivalent inactivated vaccine by using Re-11, Re-12, and H7-Re2 vaccine seed viruses, which were generated by reverse genetics and derived their HA genes from A/duck/Guizhou/S4184/2017(H5N6) (DK/GZ/S4184/17) (a clade 2.3.4.4d virus), A/chicken/Liaoning/SD007/2017(H5N1) (CK/LN/SD007/17) (a clade 2.3.2.1d virus), and A/chicken/Guangxi/SD098/2017(H7N9) (CK/GX/SD098/17), respectively. The protective efficacy of this novel vaccine and that of the recently used H5/H7 bivalent inactivated vaccine against different H5 and H7N9 viruses was evaluated in chickens. We found that the H5/H7 bivalent vaccine provided solid protection against the H7N9 virus CK/GX/SD098/17, but only 50–60% protection against different H5 viruses. In contrast, the novel H5/H7 trivalent vaccine provided complete protection against the H5 and H7 viruses tested. Our study underscores the importance of timely updating of vaccines for avian influenza control.

Published
2020
Full Text
View/download PDF

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