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Geroprotectors slow down aging and promote healthy longevity in model animals. Although hundreds of compounds have been shown to extend the life of laboratory model organisms, clinical studies on potential geroprotectors are exceedingly rare, especially in healthy elders. This review aims to classify potential geroprotectors based on the mechanisms by which they influence aging. These pharmacological interventions can be classified into the following groups: those that prevent oxidation; proteostasis regulators; suppressors of genomic instability; epigenetic drugs; those that preserve mitochondrial function; inhibitors of aging-associated signaling pathways; hormetins; senolytics/senostatics; anti-inflammatory drugs; antifibrotic agents; neurotrophic factors; factors preventing the impairment of barrier function; immunomodulators; and prebiotics, metabiotics, and enterosorbents., Competing Interests: Declaration of interests J.P.M. is CSO of Centaura, a company that aims to prevent and reverse aging, an advisor for the Longevity Vision Fund, NOVOS, and YouthBio, as well as the founder of Magellan Science Ltd, a company providing consulting services in longevity science. The other authors declare no conflicts of interest., (Copyright © 2022 Elsevier Ltd. All rights reserved.)