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2 results on '"Soteriades, S"'

1. Neuroinflammatory and morphological changes in late-life depression: the NIMROD study

Author

Su, L, Faluyi, YO, Hong, YT, Fryer, TD, Mak, E, Gabel, S, Hayes, L, Soteriades, S, Williams, GB, Arnold, R, Passamonti, L, Rodriguez, PV, Surendranathan, A, Bevan-Jones, RW, Coles, J, Aigbirhio, F, Rowe, B, O'Brien, JT, Williams, Guy [0000-0001-5223-6654], Passamonti, Luca [0000-0002-7937-0615], Surendranathan, Ajenthan [0000-0003-3809-1545], Coles, Jonathan [0000-0003-4013-679X], O'Brien, John [0000-0002-0837-5080], and Apollo - University of Cambridge Repository

Subjects
Aged, 80 and over, Cerebral Cortex, Inflammation, Male, Depressive Disorder, Major, Short Report, Hippocampus, Magnetic Resonance Imaging, Multimodal Imaging, C-Reactive Protein, Receptors, GABA, Positron-Emission Tomography, Humans, Female, Aged
Abstract

We studied neuroinflammation in individuals with late-life, depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.

Published
2016

2. Neuroinflammatory and morphological changes in late-life depression: the NIMROD study

Author

Su, L, Faluyi, YO, Hong, YT, Fryer, TD, Mak, E, Gabel, S, Hayes, L, Soteriades, S, Williams, GB, Arnold, R, Passamonti, L, Rodríguez, P Vázquez, Surendranathan, A, Bevan-Jones, RW, Coles, J, Aigbirhio, F, Rowe, JB, and O'Brien, JT

Subjects
Aged, 80 and over, Cerebral Cortex, Inflammation, Male, Depressive Disorder, Major, Hippocampus, Magnetic Resonance Imaging, Multimodal Imaging, 3. Good health, C-Reactive Protein, Receptors, GABA, Positron-Emission Tomography, Humans, Female, Aged
Abstract

We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.

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