1. Potential utility of p63 expression in differential diagnosis of non-small-cell lung carcinoma and its effect on prognosis of the disease
- Author
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Bir F, Aksoy Altınboga A, Satiroglu Tufan NL, Kaya S, Baser S, and Yaren A
- Subjects
stomatognathic diseases ,Adenocarcinoma/metabolism ,Aged ,Biomarkers, Tumor/*metabolism ,Carcinoma, Large Cell/metabolism ,Carcinoma, Non-Small-Cell Lung/*diagnosis/*metabolism ,Carcinoma, Squamous Cell/metabolism ,Diagnosis, Differential ,Female ,Humans ,Immunohistochemistry ,Male ,Membrane Proteins/*metabolism ,Middle Aged ,Prognosis ,RNA, Messenger/*metabolism ,Reverse Transcriptase Polymerase Chain Reaction/methods ,Turkey - Abstract
BACKGROUND: P63 is a gene located in chromosome 3q27-29, which has been implicated in regulation of stem cell commitment and promotion of squamous differentiation in various tissues. The aim of this study was to investigate whether there was a correlation between p63 expression, differential diagnosis of lung carcinoma, and prognosis. MATERIAL AND METHODS: Immunohistochemical expression of p63 in 62 lung carcinomas was investigated and mRNA analysis using RT-PCR method was done in 6 selected cases. RESULTS: When cases were evaluated for p63 staining, 24 of 25 (96%) squamous cell carcinomas were strongly positive. Six of 20 adenocarcinomas (25%) and 1 (100%) large cell carcinoma (except neuroendocrine carcinoma) were mildly positive. p63 staining was statistically significant in favor of squamous cell carcinoma than other tumors (p
- Published
- 2014