1. Reference values for local arterial stiffness. Part B: femoral artery
- Author
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Bossuyt, Jelle, Engelen, Lian, Ferreira, Isabel, Stehouwer, Coen, Boutouyrie, Pierre, Laurent, Stéphane, Segers, Patrick, Reesink, Koen, Bortel, Luc Van, Mattace Raso, Francesco US, Hofman, Albert, Franco, Oscar H, Kavousi, Maryam, Rooij, Frank J. A. van, Jouven, Xavier, Empana, Jean Philippe, Bozec, Erwan, Khettab, Hakim, Simon, Tabassome, Pannier, Bruno, Bots, Michiel L., Grobbee, Diederick E., Uiterwaal, Cuno S., Evelein, Annemieke, Graaf, Yolanda van der, Visseren, Frank L. J., Rietzschel, Ernst, Bacquer, Dirk De, Daele, Caroline Van, Buyzere, Marc De, Dekker, Jacqueline, Nijpels, Giel, Twisk, Jos, Smulders, Yvo, Schalkwijk, Casper, Greevenbroek, Marleen van, Kallen, Carla van der, Laar, Roel van de, Feskens, Edith, Staessen, Jan, Thijs, Lutgarde, Kouznetsova, Tatyana, Jin, Yu, Liu, Yanping, Wang, Jiguang, Yan, Li, Bianchini, Elisabetta, Ghiadoni, Lorenzo, Bruno, ROSA MARIA, Pratali, Lorenza, Taddei, Stefano, Fischer, Joachim, Terris, Darcey, Jarczok, Marc, Thole, Maren, Ryliskyte, Ligita, Laucevicius, Aleksandras, Ryliskiene, Kristina, Kuzmickiene, Jurgita, Heuten, Hilde, Goovaerts, Inge, Ennekens, Guy, Vrints, Christiaan, Tolezani, Elaine C, Hong, Valéria, Bortolotto, Luiz, Benetos, Athanase, Labat, Carlos, Lacolley, Patrick, Rimoldi, Stefano F, Stucki, Fabian, Hutter, Damian, Rexhaj, Emrush, Faita, Francesco, Sartori, Claudio, Scherrer, Urs, Allemann, Yves, Giannattasio, Cristina, Nava, Stefano, Maloberti, Alessandro, Meani, Paolo, Vermeer, Cees, Knapen, Marjo, Drummen, Nadja, Kollai, Márk, Pintér, Alexandra, Horváth, Tamás, Thuillez, Christian, Joannidès, Robinson, Bellien, Jérémy, Delahousse, Michel, Karras, Alexandre, Vanmolkot, Floris, Hoon, Jan de, Narkiewicz, Krzysztof, Szyndler, Anna, Hoffmann, Michał, Nowak, Robert, Polonis, Katarzyna, Filipovský, Jan, Agharazii, Mohsen, Briet, Marie, Interne Geneeskunde, MUMC+: MA Interne Geneeskunde (3), Biomedische Technologie, RS: CARIM - R2 - Cardiac function and failure, RS: CARIM - R3 - Vascular biology, and MUMC+: KIO Kemta (9)
- Subjects
Adult ,Male ,Mean arterial pressure ,medicine.medical_specialty ,Adolescent ,Physiology ,Population ,Femoral artery ,Young Adult ,Vascular Stiffness ,Reference Values ,medicine.artery ,Internal medicine ,Internal Medicine ,medicine ,80 and over ,risk factors ,Humans ,education ,Pulse wave velocity ,Aged ,Aged, 80 and over ,Aorta ,education.field_of_study ,business.industry ,Middle Aged ,medicine.disease ,Pulse pressure ,Surgery ,Femoral Artery ,arterial stiffness ,ageing ,Cardiology ,Arterial stiffness ,Aortic stiffness ,Female ,femoral artery ,reference values ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVE: Carotid-femoral pulse wave velocity (PWV) is considered the gold standard measure of arterial stiffness, representing mainly aortic stiffness. As compared with the elastic carotid and aorta, the more muscular femoral artery may be differently associated with cardiovascular risk factors (CV-RFs), or, as shown in a recent study, provide additional predictive information beyond carotid-femoral PWV. Still, clinical application is hampered by the absence of reference values. Therefore, our aim was to establish age and sex-specific reference values for femoral stiffness in healthy individuals and to investigate the associations with CV-RFs.METHODS: Femoral artery distensibility coefficient, the inverse of stiffness, was calculated as the ratio of relative diastolic-systolic distension (obtained from ultrasound echo-tracking) and pulse pressure among 5069 individuals (49.5% men, age range: 15-87 years). Individuals without cardiovascular disease (CVD), CV-RFs and medication use (n = 1489; 43% men) constituted a healthy subpopulation used to establish sex-specific equations for percentiles of femoral artery distensibility coefficient across age.RESULTS: In the total population, femoral artery distensibility coefficient Z-scores were independently associated with BMI, mean arterial pressure (MAP) and total to high-density lipoprotein (HDL) cholesterol ratio. Standardized βs, in men and women, respectively, were -0.18 [95% confidence interval (95% CI) -0.23 to -0.13] and -0.19 (-0.23 to -0.14) for BMI; -0.13 (-0.18 to -0.08) and -0.05 (-0.10 to -0.01) for MAP; and -0.07 (-0.11 to -0.02) and -0.16 (-0.20 to -0.11) for total-to-HDL cholesterol ratio.CONCLUSION: In young and middle-aged men and women, normal femoral artery stiffness does not change substantially with age up to the sixth decade. CV-RFs related to metabolic disease are associated with femoral artery stiffness.
- Published
- 2015