18 results on '"P-J, Ousset"'
Search Results
2. A randomized trial of the impact of a specific care plan in 1120 Alzheimer's patients (PLASA Study) over a two-year period: design and baseline data
- Author
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F, Nourhashemi, S, Gillette-Guyonnet, S, Andrieu, Y, Rolland, P-J, Ousset, B, Vellas, and Idiri
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Gerontology ,Male ,medicine.medical_specialty ,Randomization ,Time Factors ,Health Services for the Aged ,Medicine (miscellaneous) ,Disease cluster ,law.invention ,Cohort Studies ,Randomized controlled trial ,law ,Alzheimer Disease ,Activities of Daily Living ,Outcome Assessment, Health Care ,medicine ,Dementia ,Cluster Analysis ,Humans ,Cluster randomised controlled trial ,Prospective Studies ,Aged ,Aged, 80 and over ,Nutrition and Dietetics ,business.industry ,medicine.disease ,Treatment Outcome ,Cohort ,Clinical Global Impression ,Physical therapy ,Quality of Life ,Female ,Patient Care ,Geriatrics and Gerontology ,Alzheimer's disease ,business - Abstract
Objectives: To describe the design and baseline patient characteristics of a multicomponent specific care and assistance plan (PLASA) study in Alzheimer’s Disease (AD). The study is designed to evaluate the effect of PLASA in AD primarily looking at change in functional capacity.Design: Two-years prospective cluster randomized controlled trial comparing PLASA and usual care. Setting: Forty-nine hospitals in France.Participants: 1120 community-dwelling AD.Intervention: Patients in the intervention group are evaluated bi-annually using a standardized comprehensive global assessment. In the case of decline in any one domain a standardized study protocol recommends specific physician directed intervention in addition to information and training for the caregiver.Measurements: Alzheimer Disease Cooperative Study-Activities of Daily Living scale, Resource Utilization in Dementia scale, Clinical Global Impression of Change.Results: At baseline, the two groups were similar regarding patient and caregiver characteristics. The mean patient age was 79.61 + 5.72 years and the mean MMSE 19.73 + 4.01 for the whole cohort. Time since dementia diagnosis was about 1.37 + 1.65 years in the whole cohort. Almost a third of the patients lived alone at baseline. Mean monthly time spent in caregiving in the whole cohort was 52.70 + 71.83 hours for instrumental activities and 17.73 + 51.38 hours for basic activities.Conclusion: Persons with dementia suffer different losses at different stages of the disease and therefore accurate assessment of abilities and losses is critical to assist the person in planning for their future and for care needs. The PLASA intervention study is ongoing with 2 year follow-up to be completed in 2007.
- Published
- 2008
3. The ICTUS Study: A Prospective longitudinal observational study of 1,380 AD patients in Europe. Study design and baseline characteristics of the cohort
- Author
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E, Reynish, F, Cortes, S, Andrieu, C, Cantet, M, Olde Rikkert, R, Melis, L, Froelich, G B, Frisoni, L, Jönsson, P J, Visser, P J, Ousset, and B, Vellas
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Aged, 80 and over ,Cohort Studies ,Europe ,Male ,Cross-Sectional Studies ,Treatment Outcome ,Socioeconomic Factors ,Alzheimer Disease ,Epidemiologic Research Design ,Humans ,Female ,Practice Patterns, Physicians' ,Aged - Abstract
The long-term objective of the ICTUS study is to identify milestones in Alzheimer's disease (AD) progression and to develop a model to predict disease course in individual AD patients in Europe. The secondary objectives are to describe the patterns of prescribing, and the socioeconomic impact of AD in Europe. Between 2003 and 2005 1,380 patients with probable AD were recruited in specialised (secondary care) clinics in 12 European countries. Their mean age was 76 years and they had a mean of 8.0 +/- (SD) 4.6 years of education. Thirty-five percent were male. The mean MMSE score was 20.4 +/- (SD) 4.0. Forty-three percent had very mild dementia (CDR 0.5) and 44% had mild dementia (CDR 1). All patients completed baseline evaluation and biannual follow-up is ongoing. The goals of the current study are to describe the specific methods for recruitment in this crosscultural setting and the characteristics of the inception ICTUS cohort, including clinical features, co-morbidity, neuropsychological performance, neuropsychiatric symptoms, functional impairment and social burden.
- Published
- 2007
4. [Consensus statement on severe dementia]
- Author
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B, Vellas, S, Gauthier, H, Allain, S, Andrieu, J-P, Aquino, G, Berrut, M, Berthel, F, Blanchard, V, Camus, J-F, Dartigues, B, Dubois, F, Forette, A, Franco, R, Gonthier, A, Grand, M-P, Hervy, C, Jeandel, M-E, Joel, P, Jouanny, F, Lebert, P, Michot, J-L, Montastruc, F, Nourhashemi, P-J, Ousset, J, Pariente, A-S, Rigaud, P, Robert, G, Ruault, D, Strubel, J, Touchon, M, Verny, and J-M, Vetel
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Consensus ,Brain ,Continuity of Patient Care ,Neuropsychological Tests ,Severity of Illness Index ,Diagnosis, Differential ,Hospitalization ,Disability Evaluation ,Patient Rights ,Caregivers ,Alzheimer Disease ,Humans ,Dementia ,Cognition Disorders ,Geriatric Assessment ,Aged - Abstract
Under the auspices of the French Society of Gerontology and Geriatrics, a multidisciplinary group of experts, including geriatricians, neurologists, epidemiologists, psychiatrists, pharmacologists, and public health specialists developed consensus recommendations about care for patients with severe dementia. They defined 21 recommendations for general practitioners, long-term care physicians, and specialists, based on the knowledge currently available (2005). The aim of care at all stages is to mitigate the quality-of-life of patient, caregiver, and family insofar as possible, combining care and future planning until the end of life. Management, to take into account problems including nutritional status, behavior disorders, and ability (or inability) to perform activities of daily living, must be global, multidisciplinary, and coordinated and must optimize use of local medical and social resources. The group also stressed the importance of clinical research to improve knowledge of disease course and assess management strategies and recommended specific area for research.
- Published
- 2005
5. Consensus statement on dementia of Alzheimer type in the severe stage
- Author
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B, Vellas, S, Gauthier, H, Allain, S, Andrieu, J P, Aquino, G, Berrut, M, Berthel, F, Blanchard, V, Camus, J F, Dartigues, B, Dubois, F, Forette, A, Franco, R, Gonthier, A, Grand, M P, Hervy, C, Jeandel, M E, Joel, P, Jouanny, F, Lebert, P, Michot, J L, Montastruc, F, Nourhashemi, P J, Ousset, J, Pariente, A S, Rigaud, P, Robert, G, Ruault, D, Strubel, J, Touchon, M, Verny, and J M, Vetel
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Aged, 80 and over ,Male ,Aging ,Cost of Illness ,Alzheimer Disease ,Health Services for the Aged ,Activities of Daily Living ,Humans ,Institutionalization ,Female ,Geriatric Assessment ,Severity of Illness Index ,Aged - Published
- 2005
6. Impact of nutritional status on the evolution of Alzheimer's disease and on response to acetylcholinesterase inhibitor treatment
- Author
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B, Vellas, S, Lauque, S, Gillette-Guyonnet, S, Andrieu, F, Cortes, F, Nourhashémi, C, Cantet, P J, Ousset, and H, Grandjean
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Male ,Malnutrition ,Nutritional Status ,Nutrition Assessment ,Sex Factors ,Alzheimer Disease ,Risk Factors ,Disease Progression ,Humans ,Female ,Cholinesterase Inhibitors ,Prospective Studies ,Aged ,Follow-Up Studies - Abstract
Weight loss is frequently observed in patients with Alzheimer's disease (AD), as observed in clinical practice and reported in the literature. However, information on the evolution of nutritional status and its impact on the prognosis of AD is still scarce.Our aim was to determine the impact of nutritional status on the evolution of AD and on the response to treatment with acetylcholinesterase inhibitors (AChEI) by prospective one-year follow-up of AD patients living at home.We studied a cohort of 523 patients with Alzheimer's disease referred from 1994 to 2002 to an Alzheimer centre. After diagnosis, they were followed for one year in a prospective observational study in clinical practice. At entry and every 6 months, patients underwent standardised neurocognitive and geriatric evaluation (MMSE, ADAS-cog, IADL, MNA, caregiver burden). These evaluations were accompanied by complete clinical examination, standard paraclinical investigations and recording of treatment received.Of our patients, 25.8% presented at inclusion a risk of undernutrition with an MNA score of 23.5 or less. During follow-up, the number of patients with rapid loss on the MMSE (3 points or more in one year) was higher in subjects who presented a risk of undernutrition at inclusion (53.6%) than in well-nourished subjects (43.2%) (P = 0.07). Similarly, increased dependence at one year was more frequent in subjects at risk of undernutrition at inclusion (57.7% versus 44.4%, P = 0.0219). The beneficial effect of AChEI treatment on cognitive function was not influenced by initial nutritional status; on the contrary, among the subjects at risk of undernutrition at inclusion, the risk of rapid loss on the MMSE in one year was decreased in subjects treated during follow-up compared with untreated subjects (43.9% versus 73.1% ; OR = 0.29; 95% CI = 0.10-0.83; P = 0.0219). This relationship was not found in subjects whose initial MNA score was greater than 23.5.Our work indicates that AD patients living at home with a caregiver are frequently at risk of undernutrition. Undernourished patients seem to present more rapid aggravation of the disease, but paradoxically, these patients appear to be those who best respond to AChEI treatment.
- Published
- 2005
7. [Rapid loss of the Mini Mental State Examination: REAL.FR study]
- Author
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C, Dumont, S, Gillette-Guyonnet, S, Andrieu, C, Cantet, P J, Ousset, and B, Vellas
- Subjects
Male ,Cross-Sectional Studies ,Time Factors ,Alzheimer Disease ,Humans ,Female ,Prospective Studies ,Cognition Disorders ,Mental Status Schedule ,Aged ,Follow-Up Studies - Abstract
Alzheimer's disease is a chronic pathology requiring regular follow-up. The predictive factors of rapid cognitive decline remain unclear.To analyse the baselines characteristics of patients at increased risk of rapid cognitive decline.This study presents transversal data on a community-based sample of 340 patients diagnosed with probable Alzheimer's disease and followed by REAL.FR group. Rapid cognitive decline was defined as a 3-points or greater loss on the Mini Mental State Examination (MMSE) within six months.54% of patients presented a rapid cognitive decline. Logistic regression analysis showed a positive association between rapid cognitive decline and a MMSEor = 20 (p0.003) or a greater BMI (p0.02) and a tendency towards a negative correlation with anxiety (p = 0.06) and negative correlation with the burden severity (p0.05).Patients with a worse cognitive status, a greater BMI and less anxiety or burden were at increased risk of rapid cognitive decline. Future studies should focus on determining etiologies for patients with rapid cognitive loss and help clinicians target these patients for interventions aiming to delay or stabilise the course of this disease.
- Published
- 2004
8. [The French network multicenter study. Predictive factors of hospitalization and management of Alzheimer's disease patients (REAL.FR)]
- Author
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S, Gillette-Guyonnet, S, Andrieu, F, Nourhashémi, L, Balardy, M, Micas, P J, Ousset, and B, Vellas
- Subjects
Hospitalization ,Alzheimer Disease ,Humans ,France ,Prospective Studies ,Prognosis ,Aged ,Follow-Up Studies - Abstract
We present in this article the REAL.FR research program on Alzheimer disease (AD) and its management. This is a French multicenter prospective study whose objectives are to study the natural history of AD and the modalities of its management. In order to pursue these aims, we set up a cohort of 700 AD patients in France. They entered the study in year 2000 and will be followed for at least four years. The study population consists of AD patients, living in the community at the time of enrollment and looked after by an informal caregiver. On inclusion, each patient underwent a full investigation which included gerontological and social evaluation. Patients will be seen every six months for at least four years. During follow-up, events which have occurred during the previous six months are noted (i.e. admissions to hospital or to an institution, use of new in-home help services...). To date, 577 patients have been reviewed at 6 month, 489 at 12 month, 358 at 18 month, 266 at 24 month, 178 at 30 month and 31 at 36 month. 48 death have been registered, 42 patients have been institutionalised and 124 have been dropped out. Mean age of patients on inclusion was 77.4 +/- 7 years. Nearly one-third of patients were living at home when they were enrolled in the study. Our preliminary results are encouraging regarding the feasibility of patients follow-up. The satisfactory participation of patients and their families in the later evaluations which have already been carried out also seem promising for the continuation of follow-up.
- Published
- 2004
9. [Clinical evaluation of dementia in a cohort of 358 patients with the French version of the Clinical Dementia Rating (CDR) scale]
- Author
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P J, Ousset, S, Andrieu, E, Reynish, M, Puel, and B, Vellas
- Subjects
Cohort Studies ,Male ,Psychiatric Status Rating Scales ,Humans ,Dementia ,Female ,France ,Aged - Abstract
A reliable global rating of dementia severity in Alzheimer's disease is critical both in clinical and research practice. In this paper, we present the results of the assessment of a cohort of 358 patients using the French version of the Clinical Dementia Rating Scale (CDR).358 patients from a multicentric cohort were assessed in a comprehensive way: cognitive (Mini Mental Status Examination), functional (Activities of Daily Living), behavioural (Neuro Psychiatric Inventory) and global (Global Dementia Scale). CDR staging was performed after both patient and caregiver interview.27.6% of the patient had a CDR 0.5 (questionable dementia), 43% CDR 1 (mild dementia), 24.9% CDR 2 (moderate dementia) and 4.5% CDR 3 (severe dementia). All the rating scales were highly correlated with CDR stages (p0.0001). The CDR was also correlated with the Global Dementia Scale (p0.0001), but a perfect overlap of individual stages was not achieved.CDR staging takes into account the major domains of dementia assessment: cognition, function and behaviour. Staging Alzheimer's patients as CDR 0.5 arises the issue of the relationship between very mild dementia and Mild Cognitive Impairment. This study represents the first step of the CDR (French version) validation which is underway in this cohort.
- Published
- 2004
10. [Wandering and Alzheimer's type disease. Descriptive study. REAL.FR research program on Alzheimer's disease and management]
- Author
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Y, Rolland, S, Gillette-Guyonnet, F, Nourhashémi, S, Andrieu, C, Cantet, P, Payoux, P J, Ousset, and B, Vellas
- Subjects
Aged, 80 and over ,Male ,Behavior ,Alzheimer Disease ,Humans ,Female ,Prospective Studies ,Middle Aged ,Aged - Abstract
Wandering is a common problem among patients with Alzheimer's disease. Few studies have examined this problematic behaviour in the community. The aim of the present study was to increase our understanding of wandering during Alzheimer's disease in subjects living in the community.We studied 571 patients with Alzheimer's disease living in the community. Objective cognitive status was assessed using a series of standardized neuropsychological tests. Nutritional assessment, risk of fall, autonomy were assessed as well as the burden of their family. The behavioural abnormalities of patients were assessed with their caregiver using the Neuro-Psychiatric Inventory. Patients with or without wandering were described.Prevalence of wandering was 12.6%. Patients with wandering appeared to have more severe cognitive impairment, less autonomy and were undernourished. Behavioural and psychological signs significantly associated with wandering were delirium, aggressiveness, irritability, depression, anxiety, euphoria, apathy, desinhibition and eating behaviour disorder. Subtype of Alzheimer's disease patients seemed to have frontal release behaviour.Wandering is a common behaviour in Alzheimer's disease patients living in the community. Special care must be organized to help those frail patients and their caregivers.
- Published
- 2004
11. ['The 5 words': a simple and sensitive test for the diagnosis of Alzheimer's disease]
- Author
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B, Dubois, J, Touchon, F, Portet, P J, Ousset, B, Vellas, and B, Michel
- Subjects
Aged, 80 and over ,Male ,Memory Disorders ,Time Factors ,Trail Making Test ,Age Factors ,Middle Aged ,Neuropsychological Tests ,Sensitivity and Specificity ,Diagnosis, Differential ,ROC Curve ,Alzheimer Disease ,Brief Psychiatric Rating Scale ,Humans ,Female ,Cognition Disorders ,Mental Status Schedule ,Aged - Abstract
Alzheimer's disease (AD) is under-diagnosed in France. Today only an estimated 50% of patients are identified. Diagnosis of AD is particularly difficult because the amnesic syndrome, characteristic of the disease, is often confused with memory dysfunction that is frequent during the process of aging. The improvement in the diagnostic conditions of AD relies on the availability of a simple and reliable tool for screening memory disorders of organic origin.The 5-word test studies the recall of a short list, which the physician ensures the patient has registered. Its construction permits the identification of patients exhibiting objective memory disorders. A validation study has been conducted in 86 patients suffering from AD and 126 persons complaining of functional memory disorders.The study has shown the sensitivity (91%) and specificity (87%) of the 5-word test in identifying patients with AD.This is a rapid (2 minutes) and simple test that is easy to use in medical practice for the screening of AD.
- Published
- 2002
12. Mini Nutritional Assessment and Alzheimer patients
- Author
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F, Nourhashemi, S, Guyonnet, P J, Ousset, V, Kostek, S, Lauque, W C, Chumlea, B, Vellas, and J L, Albarède
- Subjects
Male ,Nutrition Assessment ,Alzheimer Disease ,Activities of Daily Living ,Weight Loss ,Humans ,Female ,Longitudinal Studies ,Serum Albumin ,Aged ,Nutrition Disorders - Published
- 2001
13. Nutritional risk factors for institutional placement in Alzheimer's disease after one year follow-up
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S, Andrieu, W, Reynish, F, Nourhashemi, P J, Ousset, H, Grandjean, A, Grand, J L, Albarede, and B, Vellas
- Subjects
Aged, 80 and over ,Male ,Institutionalization ,Nutritional Status ,Middle Aged ,Body Mass Index ,Nutrition Disorders ,Cohort Studies ,Nutrition Assessment ,Alzheimer Disease ,Risk Factors ,Activities of Daily Living ,Multivariate Analysis ,Homes for the Aged ,Humans ,Dementia ,Female ,France ,Longitudinal Studies ,Serum Albumin ,Aged ,Follow-Up Studies - Abstract
Amongst factors associated with the institutional placement of elderly people with dementia, there has been little study of those related to malnutrition. We followed a cohort of 318 individuals with Alzheimer's disease (AD). Patients, who were all living at home at the start of the study were recruited from the outpatient service of a hospital unit specialising in AD. After one year, 20% of the patients had moved into institutional care. Multivariate analysis showed that a Mini nutritional Assessment score (MNA) of less than 25.5 (median score of the sample) and overeating behavioural problems (p=0.006) were risk factors for institutional placement. Nutritional problems are reversible and patients with a low MNA score could benefit from a thorough geriatric assessment, in order to slow or prevent institutional placement.
- Published
- 2001
14. [Falls, frailty and osteoporosis in the elderly: a public health problem]
- Author
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B, Vellas, S, Gillette-Guyonnet, F, Nourhashémi, Y, Rolland, S, Lauque, P J, Ousset, S, Moulias, S, Andrieu, B, Fontan, D, Adoue, C, Lafont, R, Baumgartner, P, Garry, and J L, Albarède
- Subjects
Male ,Geriatrics ,Risk Factors ,Frail Elderly ,Humans ,Osteoporosis ,Accidental Falls ,Female ,Public Health ,Aged - Abstract
Elderly people can be subdivided into three groups: healthy elderly persons (65-70% of the population), elderly subjects with diseases (about 5%) and frail old people. Frailty represents "age-related physiologic vulnerability resulting from impaired homeotasic stock and a reduced capacity of the organism to withstand stress". It could lead elderly subjects to pathological, barely reversible, ageing.One of the main objective of geriatricians is to develop useful screening tools to identify people at high risk, thus allowing them to benefit from preventive interventions as early as possible. It has been suggested that the decline in homeostatic stock involves numerous physiological systems. Those at the core of frailty would be neuromuscular changes resulting in sarcopenia, neuroendocrine dysregulation, and immune disorders. A recent study has shown that increased levels of interleukin 6 is a risk factor for frailty.Work in progress aimed at identification of at-risk patients should: lead to early detection; draw attention on underestimated fields such as the nutritional status, sarcopenia, or gait disorders; promote the development of the standardized gerontological evaluation in order to identify the different components of frailty; and promote the development of non-pharmacological programmes including physical training, nutritional managing, and optimal social life.
- Published
- 2000
15. [Treatments of Alzheimer's disease]
- Author
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C, Vidal, N, Sastre, and P J, Ousset
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Cognitive Behavioral Therapy ,Alzheimer Disease ,Depression ,Sleep Initiation and Maintenance Disorders ,Tacrine ,Humans ,Cholinesterase Inhibitors ,Aged - Published
- 2000
16. [Falls, fragility and osteoporosis in elderly persons: a public health problem]
- Author
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B, Vellas, S, Gillette-Guyonnet, F, Nourhashemi, Y, Rolland, S, Lauque, P J, Ousset, S, Moulias, S, Andrieu, C, Lafont, D, Adoue, R J, Baumgartner, P J, Garry, and J L, Albarède
- Subjects
Aged, 80 and over ,Male ,Muscular Diseases ,Frail Elderly ,Activities of Daily Living ,Humans ,Osteoporosis ,Accidental Falls ,Female ,Public Health ,Cognition Disorders ,Aged - Published
- 2000
17. [Main syndromes revealed in a consultation specially focusing on memory]
- Author
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S, Petit, P J, Ousset, C, Pigois, A, Agniel, D, Cardebat, J F, Demonet, L, Schmitt, and M, Puel
- Subjects
Adult ,Aged, 80 and over ,Male ,Brain Diseases ,Depressive Disorder ,Memory Disorders ,Hospital Departments ,Middle Aged ,Neuropsychological Tests ,Anxiety Disorders ,Personality Disorders ,Neurology ,Alzheimer Disease ,Memory ,Humans ,Female ,Cognition Disorders ,Aged - Abstract
This paper reports our 2-year experience in a memory clinic practice at a University Hospital. During these 2 years, 128 patients with memory complaints were evaluated by a neurologist, a psychiatrist, a geriatrist and a neuropsychologist using a standardized test battery; only 58 of these patients actually presented with objective memory deficits. These memory impairments were mainly observed in patients with neurologic disorders (principally dementia) and in patients with psychiatric disorders (principally depression, major anxiety and psychiatric diseases with troubles of personality). The aim of this memory clinic is to identify the origin of memory disorders, provide a pharmacological treatment when required, propose appropriate assessment and follow up, and diagnose early symptoms of dementia.
- Published
- 1997
18. [Cognitive evaluation of patients with Alzheimer-type dementia by French revised version of the Hierarchic Dementia Scale]
- Author
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P J, Ousset, J F, Démonet, M, Puel, D, Cardebat, M, Micas, J L, Albarède, A, Rascol, and B, Guiraud
- Subjects
Diagnosis, Differential ,Male ,Cognition ,Psychometrics ,Alzheimer Disease ,Humans ,Dementia ,Female ,Middle Aged ,Mental Status Schedule ,Aged - Abstract
The revised French version of the Hierarchic Dementia Scale (HDS) was assessed in 88 DAT patients (30 men, 58 women, mean age: 70, MMS from 0 to 26). The HDS consisted of 20 subtests which covered the entire range of cognitive functions; each subtest was hierarchically organized. This scale has been validated by the authors in 149 control subjects (Démonet et al., 1990). The goals of the present study were to validate this scale in DAT patients in comparison with the MMS scores and to specify the cognitive impairments of our pathologic population. Results showed that the scores on the HDS were highly correlated with the MMS scores (p.0001). Some subtests of the HDS (memory subtests and mental control) allow good discrimination between mild demented patients and controls (sensibility = 80.8 p. 100, specificity = 96 p. 100). Conversely some subtests allowed a cognitive follow-up of patients for whom the MMS was no longer useful (MMS scores from 0 to 10). In conclusion, it appears that this scale is useful for drawing cognitive profile of DAT patients and to approach the heterogeneity of dementia.
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