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Background Frail older adults are predisposed to multiple comorbidities and adverse events. Recent interventional studies have shown that frailty can be improved and managed. In this study, effective individualized home-based exercise and nutrition interventions were developed for reducing frailty in older adults. Methods This study was a four-arm, single-blind, randomized controlled trial conducted between October 2015 and June 2017 at Miaoli General Hospital in Taiwan. Overall, 319 pre-frail or frail older adults were randomly assigned into one of the four study groups (control, exercise, nutrition, and exercise plus nutrition [combination]) and followed up during a 3-month intervention period and 3-month self-maintenance period. Improvement in frailty scores was the primary outcome. Secondary outcomes included improvements in physical performance and mental health. The measurements were performed at baseline, 1 month, 3 months, and 6 months. Results At the 6-month measurement, the exercise (difference in frailty score change from baseline: − 0.23; 95% confidence interval [CI]: − 0.41, − 0.05; p = 0.012), nutrition (− 0.28; 95% CI: − 0.46, − 0.11; p = 0.002), and combination (− 0.34; 95% CI: − 0.52, − 0.16; p

Objectives. To investigate the effects of practice variability combined with task-oriented electromyographic biofeedback (EMGBFB) on strength and balance in people with chronic stroke. Methods. Thirty-three participants were randomly assigned into the constant force EMGBFB tibialis anterior (TA) exercise (constant) group, the variable force EMGBFB tibialis anterior exercise (variable) group, or the upper extremity exercise without EMGBFB (control) group. Subjects in each group received 6 weekly sessions of exercise training (18 sessions, 40 minutes each). Motor outcomes were TA strength, balance (anteroposterior sway amplitude defined by limits of stability test in dynamic posturography), walking speed, Timed Up and Go test (TUGT), and six-minute walk test (6MWT). Data were measured at baseline, 1 day, 2 weeks, and 6 weeks posttraining. Results. TA strength increased significantly in both the constant and variable groups after training. Balance significantly improved only in the variable group. All participants showed improvements in walking speed, TUGT, and 6MWT. Conclusions. Task-oriented EMGBFB-assisted TA exercise training improved muscle strength in people with chronic stroke. Practicing to reach varying force levels during EMGBFB-assisted tibialis anterior exercises facilitated improvements in the ability to sway in the anteroposterior direction while standing. Our findings highlight the importance of task-oriented and motor learning principles while using the EMGBFB as an adjunct therapy in stroke rehabilitation. This trial was registered with trial registration number NCT01962662.

A longitudinal study was conducted to investigate the effects of injury type and discharge placement on mortality, falls, hospital admissions, and changes in activities of daily living (ADLs) over a 12-month period among older fallers. Of 762 community-dwelling people aged 65 years or older who visited an emergency department (ED) of a general hospital in Taiwan due to a fall, 273 sustained a hip fracture, 157 had a vertebral fracture, 47 had a distal forearm fracture, 102 had a traumatic brain injury, and 183 had soft-tissue injuries. Results showed that, compared to patients with a soft-tissue injury, those with TBI had significantly higher risks of dying (rate ratio (RR) = 3.59) and hospital admissions (RR = 3.23) and better improvement in ADLs (1.93 points) at 6 months post-injury, and those who sustained a hip fracture (4.26 and 4.41 points), a vertebral fracture (3.81 and 3.83 points), or a distal-forearm fracture (2.80 and 2.80 points) had significantly better improvement in ADLs at 6 and 12 months post-injury. Patients discharged to a nursing home had a significantly increased risk of death (RR = 2.08) and hospital admission (RR = 2.05) than those returning to their usual residence during the first year post-injury. No significant differences in the occurrence of falls during the first post-injury year were found among patients with different injury types or between those with different discharge placements. In conclusion, among the five major fall injury types in older people, TBIs result in the highest risk of death and hospital admissions, while hip and vertebral fractures exhibited the largest improvement during the first year after injury. Additionally, nursing home care may be associated with increased risks of death and hospital admissions than home care. In addition to primary prevention of falls, further research to investigate mechanisms leading to TBIs during a fall is needed to facilitate effective secondary fall-prevention programs for older people.

Background There is a lack of studies related to virtual reality (VR)-augmented balance training on postural control in people with Parkinson disease (PD). Objective The purposes of this study were: (1) to examine the effects of VR-augmented balance training on the sensory integration of postural control under varying attentional demands and (2) to compare the results with those of a conventional balance training (CB) group and an untrained control group. Design A longitudinal, randomized controlled trial was used. Setting The intervention was conducted in the clinic, and the assessment was performed in a research laboratory. Patients Forty-two people with PD (Hoehn and Yahr stages II-III) were recruited. Intervention The VR and CB groups received a 6-week balance training program. Measurements The sensory organization tests (SOTs) of computerized posturography with single- and dual-task conditions were conducted prior to training, after training, and at follow-up. Equilibrium scores, sensory ratios, and verbal reaction times (VRTs) were recorded. Results There were no significant differences in equilibrium scores or VRTs between the VR and CB groups. However, the equilibrium scores in SOT-6 (ie, unreliable vision and somatosensation) of the VR group increased significantly more than that of the control group after training. The equilibrium scores in SOT-5 (ie, unreliable somatosensation with eyes closed) of the CB group also increased significantly more than that of the control group after training. Limitations The functional significance of the improvements in equilibrium scores in the SOTs was not known, and the sample size was small. Conclusions Both VR and CB training improved sensory integration for postural control in people with PD, especially when they were deprived of sensory redundancy. However, the attentional demand for postural control was not changed after either VR or CB training.

Earlier and more intense rehabilitation benefit stroke patients. Yet, studies have caution intensive therapy during acute brain injury. This study examined the rehabilitation commencement time and intensity as predictors of functional outcomes in acute stroke patients admitted to the stroke intensive care unit (ICU).Sociodemographic, medical, rehabilitative and functional data were collected on 154 acute stroke patients. Regression analyses were used to identify predictors for the basic activities of daily living (Barthel Index, BI) and the walking ability at discharge.Rehabilitation commencement time and intensity significantly predicted the BI score at discharge after adjusting for initial severity (National Institute of Health Stroke Scale, NIHSS) and age (p0.05). For the walking function at discharge, only the rehabilitation intensity was a significant predictor after adjusting for initial severity and age (p0.05). Furthermore, with increasing rehabilitation intensity, patients with severe stroke benefited more than those with moderate stroke.Rehabilitation commencement time and intensity, after adjusting for admission functional status and severity of stroke, remained to be important predictors of stroke functional outcomes. This study supported the recommendation to commence rehabilitation early and intensively and provided evidence that this claim can be extended to acute stroke patients admitted to an ICU.

To compare the score of functional independence measure (FIM) between urban and rural residents living in long-term care facilities (LTCF) in Taiwan.A total of 437 subjects in 112 licensed LTCF in Taiwan were randomly selected by stratification strategy. Physical therapists interviewed the subjects in nursing homes (NH) and intermediate care facilities (ICF) to obtain the basic data, and the FIM score.(1) There was no significant difference in basic demographic data between urban and rural LTC subjects. (2) Most of the subjects in urban and rural LTCF were males, less than 80 years old, single/widowed, having multiple diseases, using more than one assistive devices, and having social welfare financial support. (3) Motor abilities (eating, grooming, and transfer) and cognition (comprehension, social interaction and problem solving) in rural LTCF subjects were significantly (p0.05) higher than those in urban areas as revealed by the FIM assessment. (4) The median of FIM total score of rural LTCF subjects was 90.5, which was significantly (p0.05) higher than that of urban LTCF subjects (median = 76).Some of the functional performance of subjects in rural long-term care institutions is better than those in urban areas. Our results may provide guidelines for the manpower and equipment supply estimation.

A valid, time-efficient and easy-to-use instrument is important for busy clinical settings, large scale surveys, or community screening use. The purpose of this study was to validate the mobility hierarchical disability categorization model (an abbreviated model) by investigating its concurrent validity with the multidimensional hierarchical disability categorization model (a comprehensive model) and triangulating both models with physical performance measures in older adults. 604 community-dwelling older adults of at least 60 years in age volunteered to participate. Self-reported function on mobility, instrumental activities of daily living (IADL) and activities of daily living (ADL) domains were recorded and then the disability status determined based on both the multidimensional hierarchical categorization model and the mobility hierarchical categorization model. The physical performance measures, consisting of grip strength and usual and fastest gait speeds (UGS, FGS), were collected on the same day. Both categorization models showed high correlation (γs = 0.92, p < 0.001) and agreement (kappa = 0.61, p < 0.0001). Physical performance measures demonstrated significant different group means among the disability subgroups based on both categorization models. The results of multiple regression analysis indicated that both models individually explain similar amount of variance on all physical performances, with adjustments for age, sex, and number of comorbidities. Our results found that the mobility hierarchical disability categorization model is a valid and time efficient tool for large survey or screening use.

The aim of this study was to investigate the effects of a task-oriented ambulation training program in regaining walking, balance, and activity of daily living performance for ambulation-challenged residents with walking potential in long-term care facilities.Fifty ambulation-challenged residents with walking potential were randomly assigned to an individualized task-oriented ambulation training group (30-45 mins, three times a week) or a routine nursing care control group for 4 wks. Each subject was evaluated by a blind evaluator before and after training. Walking function was assessed using walking speed, the Timed Up and Go Test, and the 6-Minute Walk Test. Balance and activities of daily living were measured using the Berg Balance Scale and the Barthel Index, respectively.The training group showed significantly more improvement in walking speed, time to complete the Timed Up and Go Test, and the total score of Berg Balance Scale from baseline to posttest than the control group did. No significant difference between groups was observed on the 6-Minute Walk Test or the Barthel Index.Ambulation-challenged residents with walking potential, as defined by slowing of walking speed with concomitant knee muscle weakness and joint range limitation, showed significant improvement in walking function and balance after a 4-wk task-oriented ambulation training in long-term care facilities.

BACKGROUND The purpose of this study was to analyze the electromyographic and kinematic characteristics of postural responses of 24 healthy older adults both prior to and immediately after a multisensory balance training period. It was hypothesized that the muscle and movement characteristics of postural responses would be optimized in the group after training. METHODS Balance was tested by determining muscle and kinematic response characteristics used in compensating for support surface displacements. Twenty-four subjects were randomly assigned to a training group or a control group. The training group received a multisensory balance training program during a 15-day training period (described in the companion article). RESULTS The results showed that the training (a) significantly shortened the onset latency of the neck flexor muscle (p < .05); (b) showed a trend toward decreasing the response frequency of antagonist muscles; (c) showed a trend toward increasing the response frequency of the trunk flexor muscles; and (d) showed a trend toward decreasing the maximal excursion of the first-trial of the ankle joint rotation. CONCLUSIONS From these results and those of the companion article, it was concluded that the multisensory balance training program had an effect in optimizing the muscle and movement characteristics of postural response in the training group older adults.

Background and Purpose— The purpose of our study was to investigate the effects of different doses of neuromuscular electrical stimulation (NMES) on upper-extremity function in acute stroke patients with severe motor deficit. Methods— Sixty-six acute stroke patients were randomized to 3 groups: high NMES, low NMES, or control. The low-NMES group received 30 minutes of stimulation per day, and the high-NMES group received 60 minutes per day, for 4 weeks. The Fugl-Meyer Motor Assessment Scale, Action Research Arm Test, and Motor Activity Log were used to assess the patients at baseline, 4 weeks, and 12 weeks post baseline (follow-up). Results— Both NMES groups showed significant improvement on Fugl-Meyer Motor Assessment and Action Research Arm Test scales compared with the control group at week 4 and follow-up. The high-NMES group showed treatment effects similar to those of the low-NMES group. Conclusions— Higher and lower doses of NMES led to similar improvements in motor function. A minimum of 10 hours of NMES in combination with regular rehabilitation may improve recovery of arm function in stroke patients during the acute stage.

Chen C-H, Lin K-H, Lu T-W, Chai H-M, Chen H-L, Tang P-F, Hu M-H: Immediate effect of lateral-wedged insole on stance and ambulation after stroke. Am J Phys Med Rehabil 2009;88:000‐000. Objective: To perform kinematic and kinetic analyses on the static standing and ambulation in subjects after stroke with and without wearing a 5-degree lateral-wedged insole. Design: Ten hemiparetic individuals with unilateral stroke were recruited. Participants performed quiet stance and ambulation with no insole wedge, paretic side wedged, and nonparetic side wedged in a random order. The vertical ground reaction force and temporal-spatial parameters of gait were measured. Symmetry index was also calculated. Results: During quiet stance, the symmetry index of weight bearing improved significantly with nonparetic side-wedged (P 0.017), but not with paretic side-wedged insoles. During ambulation, the symmetry indices of kinematic and kinetic measurements in the frontal plane were not significantly different among the three conditions. However, the contralateral knee abductor moment was significantly (P 0.05) less than that of the nonparetic limb during nonparetic side-wedged ambulation. The ipsilateral hip and knee abductor moments were significantly (P 0.05) less than the nonparetic limb during paretic side-wedged ambulation. Conclusions: Application of nonparetic side wedge insole can improve stance symmetry and tends to reduce the paretic knee abductor load during ambulation. The effects of paretic side-wedged insole are different. The present results provide guidelines for the placement of wedges in the shoes of individuals after stroke.

The purpose of this study is to examine the predictive validity of seven mobility-related performance tests to identify and predict older adults’ mobility disability status after a 2-year period. Among the 287 community-dwelling older adults who participated in the baseline assessment (physical disability status and seven performance tests), those who reported no mobility disability (n = 192) at baseline assessment were followed up at 2 years. A total of 120 participants returned for the follow-up assessment 2 years later, and those without missing data (n = 109) were used in the final analysis. Mobility disability status and seven performance measures (functional reach, timed chair stands, timed up and go, grip strength, usual and fastest gait speed, and six-minute walk) were re-assessed 2 years later. The timed chair stands (TCSs) were the only test that could significantly predict older adults’ mobility disability status 2 years later, adjusted for age and gender. The TCS is recommended for use in community screening to identify community-dwelling older adults who are at risk of future disability and who might benefit from health promotion programs.

To compare the practicality, reliability, validity, and responsiveness of the timed up and go (TUG), one-leg stand (OLS), functional reach (FR), and Tinetti balance (TB) performance measures in people aged 65 and older.A prospective study.Shin-Sher Township of Taichung County, west-central Taiwan.Twelve hundred community-dwelling older people.During an initial assessment at their residences, participants were interviewed for demographics, cognition, fall history, use of a walking aid, and activities of daily living (ADLs), in addition to completing the four balance tests. Falls were ascertained by telephone every 3 months for a 1-year follow-up; the four balance measures and ADLs were also reassessed at the end of the follow-up year.Of the four balance measures, the OLS had the lowest participation rate, and participation of people who were cognitively impaired had fallen in the previous year, used a walking aid, or suffered from an ADL disability was lower than for their counterparts. The time to complete the tests ranged from 58 seconds for OLS, to 160 seconds for the TB. All four balance measures exhibited excellent test-retest reliability and discriminant validity but poor responsiveness to fall status. The TB showed better discriminant, convergent, and predictive validities and responsiveness to ADL changes than the other three tests.According to psychometric properties, the most suitable performance measure for evaluating balance in community-dwelling older people was the TB, followed by the TUG.

*Research Division, Southern California University of Health Sciences, Whittier, California, USA Musculoskeletal Pain and Injury Research Unit, Department of Physiotherapy, University of Queensland, St. Lucia, Australia zSchool and Graduate Institute of Physical Therapy, National Taiwan University, Taipei, Taiwan, Republic of China Diplomat of American Board of Medical Radiology, Member of Clinical Magnetic Resonance Society